Aslan Gizem Inal, Otgun Ibrahim, Acer Tugba, Tepeoglu Merih, Hicsonmez Akgun
Ann Ital Chir. 2017;88:258-262.
In this study, we researched the effect of local administration of N-acetylcysteine (NAC) on postoperative intraabdominal adhesion formation in the rat models.
20 female Wistar Albino rats which were 5-7 months old are used for the study. The rats were divided into two equal groups. Group one was administered saline solution (n=10) while group two was administered NAC (n=10) after caecal abrasion. They were dissected on postoperative tenth day and were examined macroscopically and microscopically for the adhesion formation. Intraperitoneal adhesion formation was scored blinded with Evans model. The most adherent bowel section was excised for histopathologic examination. Mann Whitney U test were used for statistical analysis.
In Group one, all rats have had adhesions. None of the rats in Group two had either severe inflammatory cell reaction or dense interstitial fibrosis. Macroscopic adhesion formation and microscopic inflammatory cell reaction and interstitial fibrosis formation after surgery were less at the group two (NAC applied) (p<0.05, p<0.05, p<0.05).
We believe that the intraperitoneal single dose usage of NAC may be promising for decreasing the postoperative intraabdominal adhesions.
N-acetylcysteine, Postoperative adhesion, Rat, Fibrosis.
在本研究中，我们研究了局部给予N - 乙酰半胱氨酸（NAC）对大鼠模型术后腹腔粘连形成的影响。
选用20只5 - 7月龄的雌性Wistar白化大鼠进行研究。将大鼠分为两组，每组10只。第一组在盲肠擦伤后给予生理盐水，第二组给予NAC。术后第10天解剖大鼠，对粘连形成情况进行宏观和微观检查。采用伊文斯模型对腹腔粘连形成进行盲法评分。切除粘连最严重的肠段进行组织病理学检查。采用曼 - 惠特尼U检验进行统计分析。
第一组所有大鼠均有粘连形成。第二组大鼠均无严重炎症细胞反应或致密间质纤维化。第二组（应用NAC组）术后宏观粘连形成、微观炎症细胞反应和间质纤维化形成均较少（p < 0.05，p < 0.05，p < 0.05）。
我们认为腹腔内单次使用NAC可能有望减少术后腹腔粘连。
N - 乙酰半胱氨酸；术后粘连；大鼠；纤维化
