Department of Pediatric Surgery, Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital 06230 Cebeci, Ankara, Turkey.
J Pediatr Surg. 2012 Aug;47(8):1560-5. doi: 10.1016/j.jpedsurg.2012.01.080.
After abdominal surgery, the formation of postoperative adhesion is a serious problem. The aim of the study is to evaluate the efficacy of 2 different pulmonary surfactants, poractant and beractant, on adhesion prevention in an experimental model.
An experimental intraabdominal adhesion model was created in 18 adult female rats by cecal abrasion. The rats were randomly assigned to 3 groups. Group I received no further treatment, whereas groups II and III received intraperitoneal poractant and beractant, respectively, before closing the incision. On the 15th postoperative day, all rats underwent relaparotomy, intraabdominal adhesions were scored macroscopically according to Canbaz scoring system, and the cecum in each animal was evaluated microscopically.
The median adhesion scores of group II and III rats were significantly lower when compared with group I (P = .02). Group III had a lower median adhesion score than did group II, but this did not reach significance (P > .05).
These observations suggest that intraperitoneal instillation of both pulmonary surfactants is associated with lower adhesion scores, higher adhesion-free cases, and improved histologic findings.
腹部手术后，术后粘连的形成是一个严重的问题。本研究旨在评估两种不同的肺表面活性剂，猪肺磷脂和牛肺磷脂，在实验模型中预防粘连的疗效。
通过盲肠摩擦，在 18 只成年雌性大鼠中建立了一种实验性腹腔内粘连模型。大鼠被随机分为 3 组。第 1 组未接受进一步治疗，而第 2 组和第 3 组分别在关闭切口前给予腹腔内猪肺磷脂和牛肺磷脂。在术后第 15 天，所有大鼠均进行再次剖腹术，根据 Canbaz 评分系统对腹腔内粘连进行宏观评分，并对每个动物的盲肠进行微观评估。
与第 1 组相比，第 2 组和第 3 组大鼠的粘连评分中位数明显降低（P =.02）。第 3 组的粘连评分中位数低于第 2 组，但无统计学意义（P >.05）。
这些观察结果表明，腹腔内灌注两种肺表面活性剂均与较低的粘连评分、较高的无粘连病例和改善的组织学发现相关。
