一个小鼠同源异型盒基因Hox-1.5和形态学位点Hd，定位于6号染色体上1厘摩（cM）范围内。
A mouse homeo box gene, Hox-1.5, and the morphological locus, Hd, map to within 1 cM on chromosome 6.
作者信息
Mock B A, D'Hoostelaere L A, Matthai R, Huppi K
出版信息
Genetics. 1987 Aug;116(4):607-12. doi: 10.1093/genetics/116.4.607.
Abstract
Mo-10, a homeo box-containing sequence in the Hox-1 complex of genes referred to as Hox-1.5, was found to be polymorphic in inbred and wild mice, and a strain distribution of three allelic forms of Hox-1.5 are reported. The position of Hox-1.5 was mapped in backcross experiments to within 1 cM of the hypodactyly locus on chromosome 6. This identifies the Hd mutation as a useful model for the examination of homeo box expression during mammalian development.
摘要
Mo-10是Hox-1基因复合体中一个含有同源框序列的基因，被称为Hox-1.5，在近交系和野生小鼠中被发现具有多态性，并报道了Hox-1.5三种等位基因形式的品系分布。在回交实验中，Hox-1.5的位置被定位在6号染色体上并指畸形位点1厘摩范围内。这表明Hd突变是研究哺乳动物发育过程中同源框表达的有用模型。
相似文献
1
A mouse homeo box gene, Hox-1.5, and the morphological locus, Hd, map to within 1 cM on chromosome 6.一个小鼠同源异型盒基因Hox-1.5和形态学位点Hd，定位于6号染色体上1厘摩（cM）范围内。
Genetics. 1987 Aug;116(4):607-12. doi: 10.1093/genetics/116.4.607.
2
The Hox-2 homeo box gene complex on mouse chromosome 11 is closely linked to Re.小鼠11号染色体上的Hox-2同源异型盒基因复合体与Re紧密连锁。
Genetics. 1988 Feb;118(2):319-27. doi: 10.1093/genetics/118.2.319.
3
Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13.位于染色体2q31----2q37和12q12----12q13区域的含人类同源盒基因。
Am J Hum Genet. 1987 Jul;41(1):1-15.
4
Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.含同源异型盒基因在小鼠6号染色体和人类7号染色体上的遗传及细胞遗传学定位。
EMBO J. 1986 Nov;5(11):2899-905. doi: 10.1002/j.1460-2075.1986.tb04585.x.
5
A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1.一个新的含小鼠同源异型框基因家族：Hox-7.1的分子结构、染色体定位及发育表达
Genes Dev. 1989 Jan;3(1):26-37. doi: 10.1101/gad.3.1.26.
6
Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.小鼠Hox-1.7同源框基因：克隆、染色体定位及表达
Mol Cell Biol. 1987 Oct;7(10):3836-41. doi: 10.1128/mcb.7.10.3836-3841.1987.
7
Restriction fragment length polymorphism and chromosome mapping of a mouse homeo box gene, Hox-2.1.小鼠同源异型盒基因Hox-2.1的限制性片段长度多态性及染色体定位
Biochem Genet. 1988 Dec;26(11-12):805-13. doi: 10.1007/BF02395524.
8
The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus.包含同源异型盒基因的小鼠Hox-2基因簇定位于11号染色体上靠近短尾（Ts）基因座的远端。
Cytogenet Cell Genet. 1986;42(4):236-40. doi: 10.1159/000132284.
9
Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis.位于1号染色体上的新型小鼠同源盒基因，在特定造血谱系及胚胎发育过程中表达。
Genes Dev. 1991 Apr;5(4):509-20. doi: 10.1101/gad.5.4.509.
10
Mapping of the Hox-3.1 and Myc-1.2 genes on chromosome 15 of the mouse by restriction fragment length variations.通过限制性片段长度变异对小鼠15号染色体上Hox-3.1和Myc-1.2基因进行定位。
Biochem Genet. 1990 Jun;28(5-6):257-66. doi: 10.1007/BF02401416.
引用本文的文献
1
HoxA Genes and the Fin-to-Limb Transition in Vertebrates.HoxA基因与脊椎动物的鳍到肢体转变
J Dev Biol. 2016 Feb 17;4(1):10. doi: 10.3390/jdb4010010.
2
Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.Cdkn2a是细胞周期蛋白依赖性激酶抑制剂，编码p16INK4a和p19ARF，是浆细胞瘤易感位点Pctr1的一个候选基因。
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2429-34. doi: 10.1073/pnas.95.5.2429.
3
High-resolution genetic mapping of the hypodactyly (Hd) locus on mouse chromosome 6.小鼠6号染色体上少趾（Hd）基因座的高分辨率遗传定位。
Mamm Genome. 1996 Jan;7(1):2-5. doi: 10.1007/s003359900002.
4
Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3053-7. doi: 10.1073/pnas.90.7.3053.
5
Construction of a series of congenic mice with recombinant chromosome 1 regions surrounding the genetic loci for resistance to intracellular parasites (Ity, Lsh, and Bcg), DNA repair responses (Rep-1), and the cytoskeletal protein villin (Vil).构建一系列同源小鼠，其1号重组染色体区域围绕着针对细胞内寄生虫的抗性（Ity、Lsh和Bcg）、DNA修复反应（Rep-1）以及细胞骨架蛋白绒毛蛋白（Vil）的基因座。
Infect Immun. 1994 Jan;62(1):325-8. doi: 10.1128/iai.62.1.325-328.1994.
6
The gene for mouse p58cdc2L1 (Cdc2l1) protein kinase maps to distal mouse chromosome 4.
Mamm Genome. 1994 Mar;5(3):191-2. doi: 10.1007/BF00352357.
7
Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.参与小鼠浆细胞瘤发生的肿瘤易感性基因的遗传定位。
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9499-503. doi: 10.1073/pnas.90.20.9499.
8
The gene for Lap18, leukemia-associated phosphoprotein p18 (metablastin), maps to distal mouse chromosome 4.Lap18基因，即白血病相关磷蛋白p18（变blastin），定位于小鼠4号染色体远端。
Mamm Genome. 1993;4(8):461-2. doi: 10.1007/BF00296823.
9
An Nramp-related sequence maps to mouse chromosome 17.一个与Nramp相关的序列定位于小鼠第17号染色体。
Mamm Genome. 1994 Jul;5(7):458-60. doi: 10.1007/BF00357010.
10
IL9 maps to mouse chromosome 13 and human chromosome 5.
Immunogenetics. 1990;31(4):265-70. doi: 10.1007/BF00204898.
本文引用的文献
1
Recombination between kappa chain genetic markers in the mouse.小鼠κ链遗传标记之间的重组
Immunogenetics. 1984;20(5):493-501. doi: 10.1007/BF00364352.
2
Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins.果蝇和青蛙的同源异型结构域与酵母交配型调节蛋白具有同源性。
Nature. 1984;310(5972):70-1. doi: 10.1038/310070a0.
3
Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes.克隆在早期胚胎发生过程中表达的非洲爪蟾基因，该基因编码一个与果蝇同源异型基因同源的肽段区域。
Cell. 1984 Jun;37(2):409-14. doi: 10.1016/0092-8674(84)90371-4.
4
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins.编码T细胞特异性膜相关蛋白的cDNA克隆的分离
Nature. 1984;308(5955):149-53. doi: 10.1038/308149a0.
5
Hypodactyly, a semidominant lethal mutation in mice.少趾畸形，小鼠中的一种半显性致死突变。
J Hered. 1970 Sep-Oct;61(5):219-20. doi: 10.1093/oxfordjournals.jhered.a108088.
6
Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains.基于重组近交系分析的基因连锁估计的置信限
J Hered. 1985 Nov-Dec;76(6):436-40. doi: 10.1093/oxfordjournals.jhered.a110140.
7
Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.同源含同源异型框基因在分化的人畸胎瘤细胞和小鼠胚胎中的表达。
Cell. 1985 Nov;43(1):19-28. doi: 10.1016/0092-8674(85)90008-x.
8
Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes.
Nature. 1985;314(6007):175-8. doi: 10.1038/314175a0.
9
Oromandibular limb hypogenesis syndromes.
Plast Reconstr Surg. 1985 Jul;76(1):13-24. doi: 10.1097/00006534-198507000-00003.
10
Molecular genetic analysis of the V kappa Ser group associated with two mouse light chain genetic markers. Complementary DNA cloning and southern hybridization analysis.与两个小鼠轻链遗传标记相关的VκSer组的分子遗传分析。互补DNA克隆和Southern杂交分析。
J Exp Med. 1985 Aug 1;162(2):713-28. doi: 10.1084/jem.162.2.713.
Zotero 插件