Stoyanov George S, Kitanova Martina, Dzhenkov Deyan L, Ghenev Peter, Sapundzhiev Nikolay
Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine, Medical University - Varna "Prof. Dr. Paraskev Stoyanov", Varna, Bulgaria.
Department of Neurosurgery and Ent Diseases, Division of Ent Diseases, Faculty of Medicine, Medical University - Varna "Prof. Dr. Paraskev Stoyanov", Varna, Bulgaria.
Cureus. 2017 Jul 2;9(7):e1418. doi: 10.7759/cureus.1418.
Introduction Head and neck cancer (HNC) comprises a diverse group of oncological entities, originating from various tissue types and organ localizations, situated in the topographical regions of the head and neck (H&N). This single institution retrospective study was aimed at establishing the HNC patient demographics and categorizing the individual incidence of H&N malignancies, regarding their organ of origin and main histopathological type. Materials and methods All histologically verified cases of HNC from a single tertiary referral center were reviewed in a descriptive retrospective manner. Data sampling period was 47 months. Results Male to female ratio of the registered HNC cases was 3.24:1. The mean age of diagnosis was 63.84 ± 12.65 years, median 65 years. The most common HNC locations include the larynx 30.37% (n = 188), lips and oral cavity 29.08% (n = 180), pharynx 20.03% (n = 124) and salivary glands 10.94% (n = 68), with other locations such as the external nose, nasal cavity and sinuses and auricle and external ear canal harboring a minority of the cases. The main histopathological groups include squamous cell carcinoma 76.74% (n = 475) and adenocarcinoma 6.14% (n = 38), with other malignant entries such as other epithelial malignancies, primary tonsillar, mucosa-associated lymphoid tissue or parenchymal lymphomas, connective tissue neoplasias, neuroendocrine and vascular malignancies diagnosed in a minority of cases. Conclusion Considered to be relatively rare, HNC represents a diverse group of oncological entities with individual and specific demographic characteristics. The reported single institution results appear representative of the national incidence and characteristics of HNC.
引言
头颈癌(HNC)是一组多样的肿瘤实体,起源于头颈部(H&N)地形区域的各种组织类型和器官定位。这项单机构回顾性研究旨在确定HNC患者的人口统计学特征,并根据其起源器官和主要组织病理学类型对H&N恶性肿瘤的个体发病率进行分类。
材料与方法
以描述性回顾的方式对来自单个三级转诊中心的所有经组织学证实的HNC病例进行了审查。数据采样期为47个月。
结果
登记的HNC病例的男女比例为3.24:1。诊断的平均年龄为63.84±12.65岁,中位数为65岁。最常见的HNC部位包括喉30.37%(n = 188)、唇和口腔29.08%(n = 180)、咽20.03%(n = 124)和唾液腺10.94%(n = 68),其他部位如外鼻、鼻腔和鼻窦以及耳廓和外耳道的病例较少。主要组织病理学组包括鳞状细胞癌76.74%(n = 475)和腺癌6.14%(n = 38),其他恶性病例如其他上皮性恶性肿瘤、原发性扁桃体、黏膜相关淋巴组织或实质性淋巴瘤、结缔组织肿瘤、神经内分泌和血管恶性肿瘤的诊断病例较少。
结论
HNC被认为相对罕见,是一组具有个体和特定人口统计学特征的多样肿瘤实体。所报告的单机构结果似乎代表了HNC的全国发病率和特征。