肾盂肾炎患者对致病性大肠杆菌菌毛的血清学反应
Serological response to the P fimbriae of uropathogenic Escherichia coli in pyelonephritis.
作者信息
de Ree J M, van den Bosch J F
出版信息
Infect Immun. 1987 Sep;55(9):2204-7. doi: 10.1128/iai.55.9.2204-2207.1987.
Abstract
Uropathogenic Escherichia coli strains isolated from four patients with pyelonephritis were characterized by their O:K serotype, hemolysin production, mannose-resistant hemagglutination, and the serotype of the P fimbriae. These P fimbriae were serotyped with specific monoclonal antibodies. Serum samples from the patients were analyzed for the presence of specific antibodies to the P fimbriae. In all cases antifimbrial antibodies were found, strongly suggesting that these P fimbriae are expressed in vivo. However, the antibodies in the patient sera were not able to inhibit the mannose-resistant hemagglutination. This finding suggests that these antibodies react with the fimbrial components and not with the minor components which are responsible for adhesion.
摘要
从四名肾盂肾炎患者中分离出的尿路致病性大肠杆菌菌株，通过其O:K血清型、溶血素产生、甘露糖抗性血凝反应以及P菌毛的血清型进行鉴定。这些P菌毛用特异性单克隆抗体进行血清分型。分析患者的血清样本中是否存在针对P菌毛的特异性抗体。在所有病例中均发现了抗菌毛抗体，强烈提示这些P菌毛在体内表达。然而，患者血清中的抗体无法抑制甘露糖抗性血凝反应。这一发现表明这些抗体与菌毛成分发生反应，而不是与负责黏附的次要成分发生反应。
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