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原癌基因的差异表达是周围神经系统组织病理学上难以区分的肿瘤的特征。

Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system.

作者信息

Thiele C J, McKeon C, Triche T J, Ross R A, Reynolds C P, Israel M A

出版信息

J Clin Invest. 1987 Sep;80(3):804-11. doi: 10.1172/JCI113137.

DOI:10.1172/JCI113137
PMID:2887586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC442306/
Abstract

We have found highly predictable patterns of protooncogene expression in cell lines and tumor tissue of neuroblastoma (NB), a tumor of the peripheral nervous system (PNS). These patterns make it possible to recognize two different genetically definable subgroups among histopathologically indistinguishable tumors. Additionally, we have identified a difference in neurotransmitter biosynthetic enzyme activity in these two subgroups of NB. The patterns of protooncogene expression and neurotransmitter biosynthetic enzymes suggests that these tumors arise in different cells of the PNS.

摘要

我们已经在神经母细胞瘤（NB）的细胞系和肿瘤组织中发现了原癌基因表达的高度可预测模式，神经母细胞瘤是一种外周神经系统（PNS）肿瘤。这些模式使得在组织病理学上无法区分的肿瘤中识别出两个不同的可通过基因定义的亚组成为可能。此外，我们还发现了NB这两个亚组中神经递质生物合成酶活性的差异。原癌基因表达模式和神经递质生物合成酶表明这些肿瘤起源于PNS的不同细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ab/442306/9dc2bef40cf5/jcinvest00093-0227-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ab/442306/016f7049012d/jcinvest00093-0226-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ab/442306/2777f1b16b7c/jcinvest00093-0226-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ab/442306/e1943ec2a3b2/jcinvest00093-0226-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ab/442306/0e509a6fc823/jcinvest00093-0227-a.jpg
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