脂多糖转运（Lpt）机制：革兰氏阴性菌外膜上用于脂多糖组装的一种非常规转运体。
The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria.
作者信息
Sperandeo Paola, Martorana Alessandra M, Polissi Alessandra
机构信息
From the Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan and.
the Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, 20126 Milan, Italy.
出版信息
J Biol Chem. 2017 Nov 3;292(44):17981-17990. doi: 10.1074/jbc.R117.802512. Epub 2017 Sep 6.
Abstract
The outer membrane (OM) of Gram-negative is a unique lipid bilayer containing LPS in its outer leaflet. Because of the presence of amphipathic LPS molecules, the OM behaves as an effective permeability barrier that makes Gram-negative bacteria inherently resistant to many antibiotics. This review focuses on LPS biogenesis and discusses recent advances that have contributed to our understanding of how this complex molecule is transported across the cellular envelope and is assembled at the OM outer leaflet. Clearly, this knowledge represents an important platform for the development of novel therapeutic options to manage Gram-negative infections.
摘要
革兰氏阴性菌的外膜（OM）是一种独特的脂质双层膜，其外层小叶含有脂多糖（LPS）。由于两亲性LPS分子的存在，外膜表现为一种有效的渗透屏障，使革兰氏阴性菌天然地对许多抗生素具有抗性。本综述聚焦于LPS的生物合成，并讨论了最近的进展，这些进展有助于我们理解这种复杂分子是如何穿过细胞包膜并在外膜外层小叶组装的。显然，这些知识是开发治疗革兰氏阴性菌感染新疗法的重要平台。
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