中国江西省 118730 例三级医院患者抗中性粒细胞胞浆抗体分析。
Analysis of Antineutrophil Cytoplasm Antibody from 118 730 Patients in Tertiary Hospitals in Jiangxi Province, China.
机构信息
Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
School of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
出版信息
Med Sci Monit. 2017 Sep 7;23:4312-4320. doi: 10.12659/msm.905880.
BACKGROUND The discovery of antineutrophil cytoplasm antibody (ANCA) makes the early diagnosis of primary vasculitis possible, and also has important guiding significance for the diagnosis and treatment of secondary vasculitis. This study aimed to investigate the clinical significance of ANCA. MATERIAL AND METHODS ANCA was detected by indirect immunofluorescence assay (IIF), and anti-myeloperoxidase (MPO) antibody, and anti-proteinase 3 (PR3) antibody were detected by ELISA. The results were analyzed retrospectively. RESULTS Among 118 730 patients, a total of 5853 (4.93%) were positive for ANCA. In the positive cases, 3.98% were male and 6.33% were female, with significant differences (χ²=123.38, P<0.01). For ANCA, the department with the highest positive rate (15.06%) was the Department of Rheumatology, followed by 7.78% in the Department of Dermatology, 6.79% in the Department of Nephrology, and 5.72% in the Department of Traditional Chinese Medicine (TCM). Anti-PR3 and cANCA were highly specific in primary vasculitis (P<0.01). Anti-MPO and pANCA had high specificity for other autoimmune diseases (P<0.01). CONCLUSIONS ANCA has important guiding significance for vasculitis-related diseases. Therefore, it is important in the diagnosis and treatment of this disease and has value in clinical practice.
背景
抗中性粒细胞胞浆抗体（ANCA）的发现使得原发性血管炎的早期诊断成为可能，对继发性血管炎的诊断和治疗也具有重要的指导意义。本研究旨在探讨 ANCA 的临床意义。
材料和方法
采用间接免疫荧光法（IIF）检测 ANCA，采用酶联免疫吸附试验（ELISA）检测抗髓过氧化物酶（MPO）抗体和抗蛋白酶 3（PR3）抗体。对结果进行回顾性分析。
结果
在 118730 例患者中，共有 5853 例（4.93%）ANCA 阳性。在阳性病例中，男性占 3.98%，女性占 6.33%，差异有统计学意义（χ²=123.38，P<0.01）。在 ANCA 阳性病例中，阳性率最高的科室是风湿科（15.06%），其次是皮肤科（7.78%）、肾病科（6.79%）和中医科（5.72%）。抗 PR3 和 cANCA 对原发性血管炎具有高度特异性（P<0.01）。抗 MPO 和 pANCA 对其他自身免疫性疾病具有高度特异性（P<0.01）。
结论
ANCA 对血管炎相关疾病具有重要的指导意义。因此，在诊断和治疗该疾病中具有重要意义，在临床实践中有一定的应用价值。
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