Acta Chim Slov. 2020 Mar;67(1):212-220.
The electrochemical oxidation of pantoprazole, a selective proton pump inhibitor, was studied in aqueous as well as aqueous/surfactant media at a disposable pencil graphite electrode using cyclic and adsorptive stripping voltammetric techniques. The sensitivity of the stripping voltammetric measurements was significantly improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the neutral electrolyte solution. For analytical purposes, well resolved voltammetric peaks at +1.05 V (versus Ag/AgCl) were obtained in Britton-Robinson buffer at pH 7.0 containing 3×10-4 M CTAB using square-wave stripping mode (after 30 s accumulation at open-circuit condition). The process could be used to determine pantoprazole concentrations in the range of 2.4×10-8 - 7.1×10-7 M (9.2 - 272 µg L-1) with a detection limit of 7.0×10-9 M (2.7 µg L-1). The proposed method was applied to the determination of pantoprazole in pharmaceutical formulation and in the spiked human urine samples with acceptable recoveries.
在一次性铅笔石墨电极上，在水溶液以及水/表面活性剂介质中，使用循环伏安法和吸附溶出伏安法研究了泮托拉唑（一种选择性质子泵抑制剂）的电化学氧化。当阳离子表面活性剂十六烷基三甲基溴化铵（CTAB）存在于中性电解质溶液中时，溶出伏安测量的灵敏度得到了显著提高。对于分析目的，在 pH 7.0 的 Britton-Robinson 缓冲液中，含有 3×10-4 M CTAB 的条件下，使用方波溶出模式（在开路条件下 30 秒积累后），在+1.05 V（相对于 Ag/AgCl）处获得了良好分辨的伏安峰。该方法可用于测定 2.4×10-8-7.1×10-7 M（9.2-272 µg L-1）范围内的泮托拉唑浓度，检测限为 7.0×10-9 M（2.7 µg L-1）。该方法已应用于药物制剂中泮托拉唑的测定以及人尿液中添加的泮托拉唑的测定，回收率令人满意。
