National Center on Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control and Prevention, 4770 Buford Highway MS E-86, Atlanta, GA, USA.
Center for Autism Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
J Autism Dev Disord. 2017 Nov;47(11):3634-3645. doi: 10.1007/s10803-017-3280-4.
The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
本研究旨在通过识别自闭症谱系障碍（ASD）幼儿的同质类别，以改善表型特征。研究对象为 2 至 5 岁参加早期发展研究的儿童。在经过严格的诊断算法综合评估后，有 707 名儿童被归类为 ASD。通过潜在类别分析，我们确定了 4 类 ASD 儿童：语言轻度延迟伴认知僵化、语言和运动轻度延迟伴失调、全面发育迟缓、重复性运动行为伴明显发育迟缓。我们得出结论，ASD 儿童的四分类表型模型最能描述我们的数据，并改善 ASD 幼儿的表型特征。最后讨论了对筛查、诊断和研究的影响。
