Li Wei-Xia, Zhang Hui, Tang Jin-Fa, Meng Xiang-le, Liu Pei, Meng Fei, Li Xue-Lin
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China.
Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1338-1341. doi: 10.4268/cjcmm20160728.
To analyze the clinical application characteristics of Danggui-Chuanxiong(DG-CX) herb pair in Chinese medicines on basis of real-world, and provide reference for explaining the inherent compatibility regularity and the relationship between clinical applications and disease species. From April 1, 2014 to June 30, 2014, a total of 8 792 prescriptions with both "DG"and "CX" in a large third-grade class-A traditional Chinese medicine(TCM) hospital were selected to establish the database for analyzing the ratio, dosage, and corresponding disease species of DG-CX herb pair. The results showed that, "DG-CX" with ratio "1∶1" had the highest frequency in clinical application(42.4%); the dosage was mainly of 15 g for both DG and CX; the disease species were mainly of encephalopathy and pulmonary diseases. "DG-CX" herb pairs with a ratio greater than "1∶1" accounted for 33.3% of all the prescriptions, and the ratio "3∶2" appeared to be most frequent among them; the dosage was mainly of 15 g for DG and and 10 g for CX; the disease species were mainly of encephalopathy diseases. "DG-CX" herb pairs with a ratio less than "1∶1" accounted for 24.3% of all the prescriptions, and the ratio "2∶3" appeared to be most frequent among them; the dosage was mainly of 10 g for DG and 15 g for CX; the disease species were mainly of encephalopathy diseases. Statistical method was applied to study the compatibility and application characteristics of Chinese herb pairs in clinical prescriptions, effectively discover the medication regularity, provide theoretical basis for clinical herbal prescriptions and provide scientific guidance and reliable data for modern research of Chinese herb pairs.
基于真实世界分析中药当归 - 川芎药对的临床应用特点，为阐释其内在配伍规律及临床应用与病种的关系提供参考。选取某大型三级甲等中医医院2014年4月1日至2014年6月30日期间共8792张同时含有“当归”和“川芎”的处方，建立数据库分析当归 - 川芎药对的配比、用量及相应病种。结果显示，配比为“1∶1”的“当归 - 川芎”临床应用频次最高（42.4%）；用量上当归、川芎均主要为15 g；病种主要为脑病和肺病。配比大于“1∶1”的“当归 - 川芎”药对占总处方数的33.3%，其中以“3∶2”最为常见；用量上当归主要为15 g，川芎主要为10 g；病种主要为脑病。配比小于“1∶1”的“当归 - 川芎”药对占总处方数的24.3%，其中以“2∶3”最为常见；用量上当归主要为10 g，川芎主要为15 g；病种主要为脑病。运用统计学方法研究临床处方中中药药对的配伍及应用特点，有效发掘用药规律，为临床遣方用药提供理论依据，为中药药对的现代研究提供科学指导和可靠数据。
