飞龙掌血根中的香豆素和生物碱。

Coumarins and alkaloids from the roots of Toddalia asiatica.

作者信息

Sukieum Sanwat, Sang-Aroon Wichien, Yenjai Chavi

机构信息

a Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.

b Faculty of Engineering, Department of Chemistry , Rajamangala University of Technology Isan , Khon Kaen , Thailand.

出版信息

Nat Prod Res. 2018 Apr;32(8):944-952. doi: 10.1080/14786419.2017.1374264. Epub 2017 Sep 7.

DOI:10.1080/14786419.2017.1374264

PMID:28880112

Abstract

The EtOAc and MeOH extracts of the roots of Toddalia asiatica Lam. were investigated for the roots' chemical constituents. Two new compounds including 2'R-acetoxytoddanol (1) and 8S-10-O-demethylbocconoline (3) as well as 15 known compounds were isolated. Compound 10 showed strong cytotoxicity against KB cells with an IC value of 2.60 μg/mL, which is nearly equal to the ellipticine standard, but showed no activity against Vero cells. Alkaloid 3 displayed weak cytotoxicity against the KB cell line with an IC value of 21.69 μg/mL.

摘要

对飞龙掌血（Toddalia asiatica Lam.）根的乙酸乙酯提取物和甲醇提取物进行了化学成分研究。分离得到了两种新化合物，分别为2'R-乙酰氧基飞龙醇（1）和8S-10-O-去甲基博落回碱（3）以及15种已知化合物。化合物10对KB细胞显示出较强的细胞毒性，IC值为2.60μg/mL，几乎与椭圆玫瑰树碱标准品相当，但对Vero细胞无活性。生物碱3对KB细胞系显示出较弱的细胞毒性，IC值为21.69μg/mL。