School of Science, Monash University Malaysia, Bandar Sunway, Selangor 46150, Malaysia.
School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor 46150, Malaysia.
Nutrients. 2017 Sep 7;9(9):984. doi: 10.3390/nu9090984.
The clinical value of tocotrienols is increasingly appreciated because of the unique therapeutic effects that are not shared by tocopherols. However, their effect on metabolic syndrome is not well-established. This study aimed to investigate the effects of a tocotrienol-rich fraction (TRF) from palm oil in high-fat-diet-treated rats. Male, post-weaning Sprague Dawley rats were provided high-fat (60% kcal) diet for eight weeks followed by a TRF (60 mg/kg) treatment for another four weeks. Physical, metabolic, and histological changes were compared to those on control and high-fat diets respectively. High-fat feeding for eight weeks induced all hallmarks of metabolic syndrome. The TRF reversed systolic and diastolic hypertension, hypercholesterolemia, hepatic steatosis, impaired antioxidant defense, and myeloperoxidase hyperactivity triggered by the high-fat diet. It also conferred an inhibitory effect on protein glycation to reduce glycated hemoglobin A1c and advanced glycation end products (AGE). This was accompanied by the suppression of the receptor for advanced glycation end product (RAGE) expression in the liver. The treatment effects on visceral adiposity, glycemic control, triglyceride level, as well as peroxisome proliferator-activated receptor α and γ expression were negligible. To conclude, treatment with a TRF exhibited protective effects on the cardiovascular and liver health in addition to the amelioration of plasma redox imbalance and AGE-RAGE activation. Further investigation as a therapy for metabolic syndrome is therefore worthwhile.
生育三烯酚的临床价值日益受到重视，这是因为其具有生育酚所没有的独特治疗作用。然而，其对代谢综合征的影响尚未得到充分证实。本研究旨在探讨富含生育三烯酚的棕榈油馏分（TRF）对高脂饮食大鼠的影响。雄性，断奶后的 Sprague Dawley 大鼠给予高脂（60%热量）饮食 8 周，然后再给予 TRF（60mg/kg）治疗 4 周。分别比较了其与对照组和高脂组的生理、代谢和组织学变化。高脂喂养 8 周可诱导代谢综合征的所有特征。TRF 逆转了由高脂饮食引起的收缩压和舒张压升高、高胆固醇血症、肝脂肪变性、抗氧化防御受损和髓过氧化物酶活性升高。它还对蛋白质糖基化具有抑制作用，可降低糖化血红蛋白 A1c 和晚期糖基化终产物（AGE）。这伴随着肝脏中晚期糖基化终产物受体（RAGE）表达的抑制。治疗对内脏脂肪、血糖控制、甘油三酯水平以及过氧化物酶体增殖物激活受体α和γ表达的影响可以忽略不计。总之，TRF 的治疗作用除了改善血浆氧化还原失衡和 AGE-RAGE 激活外，还对心血管和肝脏健康具有保护作用。因此，进一步将其作为代谢综合征的治疗方法进行研究是值得的。
