The Influence of Gene Polymorphisms on Infection and Triple Treatment Response Among Jordanian Population.

BACKGROUND

() is considered the main cause of gastritis, peptic ulcer and gastric carcinoma in the human populations. infection influences the secretion level of several proinflammatory cytokines including IL-1β, which encoded by the gene.

OBJECTIVE

The current study aimed to investigate whether gene polymorphisms are associated with infection among the Jordanian population and responses to triple therapy.

SUBJECTS AND METHODS

The gastroscopic examination was performed on 412 subjects for infection diagnosis, 257 subjects were found to be infected by (positive cases), whereas 155 subjects were uninfected (negative controls). The gene T-31C and C3954T polymorphisms were genotyped by PCR-RFLP.

RESULTS

It was found that the T-31C polymorphism has a significant association with infection (<0.05), and the TT genotype frequency was significantly higher in infected subjects (50.2%) compared to controls (38.7%). On the other hand, no significant association was detected between C3954T SNPs and infection among the Jordanian population. In addition, none of the examined polymorphisms were found to influence the responses to triple therapy.

CONCLUSION

The gene T-31C SNP might be associated with an enhanced risk of infection among the Jordanian population.