与小细胞肺癌相关的慢性肠道假性梗阻和体位性低血压，经放化疗后肿瘤缩小病情改善

Izumi Yusuke, Masuda Takeshi, Horimasu Yasushi, Nakashima Taku, Miyamoto Shintaro, Iwamoto Hiroshi, Fujitaka Kazunori, Hamada Hironobu, Hattori Noboru

Department of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.

Intern Med. 2017 Oct 1;56(19):2627-2631. doi: 10.2169/internalmedicine.8574-16. Epub 2017 Sep 6.

Chronic intestinal pseudo-obstruction (CIPO) is a rare disease with symptoms of ileus without obstruction. Most cases of CIPO are idiopathic, and CIPO as a paraneoplastic neurological syndrome (PNS) associated with small cell lung cancer (SCLC) is rare. A 63-year-old man was diagnosed with functional ileus and confined to bed due to orthostatic hypotension. Chest computed tomography revealed a right hilar mass suspected of being lung cancer. Based on detailed examinations, he was diagnosed with limited-stage SCLC. His symptoms were confirmed as PNS because his serum anti-Hu antibody was positive. His PNS was improved with complete tumor reduction by chemoradiotherapy.

慢性假性肠梗阻（CIPO）是一种罕见疾病，具有肠梗阻症状但无梗阻。大多数CIPO病例为特发性，而CIPO作为与小细胞肺癌（SCLC）相关的副肿瘤性神经综合征（PNS）则较为罕见。一名63岁男性被诊断为功能性肠梗阻，并因体位性低血压而卧床。胸部计算机断层扫描显示右肺门肿块，怀疑为肺癌。经过详细检查，他被诊断为局限期小细胞肺癌。由于其血清抗Hu抗体呈阳性，其症状被确认为副肿瘤性神经综合征。通过放化疗使肿瘤完全缩小后，他的副肿瘤性神经综合征得到改善。