肺癌引起的消化系统罕见副肿瘤综合征。
Rare paraneoplastic syndromes in digestive systems caused by lung cancer.
机构信息
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University, Niigata, Japan
Tsubame Rosai Hospital, Tsubame, Japan.
出版信息
BMJ Case Rep. 2021 Feb 5;14(2):e240161. doi: 10.1136/bcr-2020-240161.
We observed a rare case of two different digestive paraneoplastic syndromes that improved with the treatment of the neoplasms. The first syndrome was chronic intestinal pseudo-obstruction (CIPO), which is a subtype of paraneoplastic syndromes called a paraneoplastic neurological syndrome (PNS). The second was Stauffer's syndrome, which is a unique paraneoplastic syndrome characterised by non-metastatic intrahepatic cholestasis associated with neoplasms. Here, we report the case of a 55-year-old man who presented with two concurrent paraneoplastic syndromes in the digestive system. The intestinal pseudo-obstruction and elevated biliary enzyme levels improved as the lung cancer responded to chemotherapy. In this case, CIPO as a PNS led to the detection of lung cancer. To our knowledge, this is the first report of Stauffer's syndrome caused by lung adenocarcinoma.
我们观察到一例罕见的两种不同的消化系统副肿瘤综合征，这些综合征在肿瘤治疗后得到改善。第一种综合征是慢性肠假性梗阻（CIPO），它是一种称为副肿瘤神经系统综合征（PNS）的副肿瘤综合征的亚型。第二种是 Stauffer 综合征，这是一种独特的副肿瘤综合征，其特征是非转移性肝内胆汁淤积症与肿瘤相关。在这里，我们报告了一例 55 岁男性，他患有两种同时发生的消化系统副肿瘤综合征。随着肺癌对化疗的反应，肠假性梗阻和胆汁酶水平升高得到改善。在这种情况下，作为 PNS 的 CIPO 导致了肺癌的检测。据我们所知，这是首例由肺腺癌引起的 Stauffer 综合征的报告。
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