Sanada I, Ishii T, Matsuoka M, Kumagai E, Nishimura H, Yamaguchi K, Takatsuki K
Blood Transfusion Service, Kumamoto University Medical School, Honjo, Japan.
Hematol Oncol. 1987 Jul-Sep;5(3):157-66. doi: 10.1002/hon.2900050302.
Cytogenetic studies were done in lymph node and peripheral leukemic cells from sixteen patients with non-Hodgkin lymphoma with peripheral T-cell type. Ten patients were positive for human T-cell leukemia virus I (HTLV-I) proviral DNA in tumour cells and six were negative. The former group had a higher tendency for leukemic conversion and poorer prognosis than the latter. However, no definite difference on the numerical and structural chromosomal abnormalities between these two groups was found. The most frequent chromosome abnormalities: 14p+, 14q+ and No. 6 abnormalities were detected in both groups. These results may indicate that HTLV-I does not play a specific role in chromosome abnormalities of non-Hodgkin lymphoma with peripheral T-cell type.
对16例外周T细胞型非霍奇金淋巴瘤患者的淋巴结和外周白血病细胞进行了细胞遗传学研究。10例患者肿瘤细胞中的人T细胞白血病病毒I（HTLV-I）前病毒DNA呈阳性，6例呈阴性。前一组比后一组有更高的白血病转化倾向和更差的预后。然而，两组之间在染色体数目和结构异常方面未发现明确差异。两组均检测到最常见的染色体异常：14p+、14q+和6号染色体异常。这些结果可能表明，HTLV-I在外周T细胞型非霍奇金淋巴瘤的染色体异常中不发挥特定作用。
