因放射敏感性增加导致前列腺癌患者接受盆腔挽救性放疗后出现致死性结局：病例报告及文献复习。
Lethal outcome after pelvic salvage radiotherapy in a patient with prostate cancer due to increased radiosensitivity : Case report and literature review.
机构信息
Klinik und Praxis für Radioonkologie und Strahlentherapie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany.
Klinik für Diagnostische Radiologie, Interventionelle Radiologie und Neuroradiologie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany.
出版信息
Strahlenther Onkol. 2018 Jan;194(1):60-66. doi: 10.1007/s00066-017-1207-9. Epub 2017 Sep 8.
BACKGROUND
In general, late side effects after salvage radiotherapy (RT) for prostate cancer are below 10%. Patients with impaired DNA repair ability and genetic instability can have significantly increased reactions after RT.
CASE, CLINICAL FOLLOW-UP, AND EXAMINATION: We present a patient who experienced severe side effects after additive RT for prostate cancer and died from the complications 25 months after RT. Imaging (MR) is shown as well as three-color fluorescence in situ hybridization. The blood sample testing revealed that radiosensitivity was increased by 35-55%. We undertook a review of the literature to give an overview over the tests established that are currently considered useful.
CONCLUSION
This case highlights that the identification of patients with increased radiosensitivity is an important task in radiation protection. Groups of patients who should be screened have to be found and corresponding research facilities have to be set up.
背景
一般来说，前列腺癌挽救性放疗（RT）后的晚期副作用低于 10%。具有 DNA 修复能力受损和遗传不稳定性的患者在 RT 后可能会有明显增加的反应。
病例、临床随访和检查：我们报告了一例前列腺癌附加 RT 后出现严重副作用的患者，在 RT 后 25 个月死于并发症。影像学（MR）和三色荧光原位杂交显示。血液样本检测显示放射敏感性增加了 35-55%。我们对文献进行了回顾，以概述目前认为有用的检测方法。
结论
本病例强调了识别放射敏感性增加的患者是放射防护的一项重要任务。必须找到需要筛查的患者群体，并建立相应的研究设施。
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