Department of Radiation Oncology of the University Hospitals and Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.
Radiol Oncol. 2014 Jan 22;48(1):80-6. doi: 10.2478/raon-2013-0061. eCollection 2014 Mar.
Individual radiosensitivity has a crucial impact on radiotherapy related side effects. Our aim was to study a breast cancer collective for its variation of individual radiosensitivity depending on the patients' age.
Peripheral blood samples were obtained from 129 individuals. Individual radiosensitivity in 67 breast cancer patients and 62 healthy individuals was estimated by 3-color fluorescence in situ hybridization.
Breast cancer patients were distinctly more radiosensitive compared to healthy controls. A subgroup of 9 rather radiosensitive and 9 rather radio-resistant patients was identified. A subgroup of patients aged between 40 and 50 was distinctly more radiosensitive than younger or older patients.
In the breast cancer collective a distinct resistant and sensitive subgroup is identified, which could be subject for treatment adjustment. Preliminary results indicate that especially in the range of age 40 to 50 patients with an increased radiosensitivity are more frequent and may have an increased risk to suffer from therapy related side effects.
个体放射敏感性对放疗相关副作用有至关重要的影响。我们的目的是研究一个乳腺癌群体，根据患者年龄来研究个体放射敏感性的变化。
从 129 个人中获得外周血样本。通过三色荧光原位杂交技术，对 67 名乳腺癌患者和 62 名健康个体的个体放射敏感性进行了估计。
乳腺癌患者明显比健康对照组更具放射敏感性。确定了 9 个相对放射敏感和 9 个相对放射抵抗的患者亚组。年龄在 40 至 50 岁之间的患者亚组明显比年轻或年老的患者更具放射敏感性。
在乳腺癌群体中，确定了一个明显的抵抗和敏感亚组，这可能需要进行治疗调整。初步结果表明，尤其是在 40 至 50 岁的年龄范围内，具有较高放射敏感性的患者更为常见，并且可能有更高的风险遭受与治疗相关的副作用。
