CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Department of Psychiatry, Academic Medical Centre at the University of Amsterdam & Arq Psychotrauma Expert Group, Diemen, Netherlands.
Neurosci Biobehav Rev. 2017 Dec;83:647-656. doi: 10.1016/j.neubiorev.2017.08.021. Epub 2017 Sep 6.
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric syndrome with complex etiology. Studies aiming to explore genetic susceptibility and environmental triggers of PTSD have been increasing. However, the results are limited and highly heterogeneous. To understand the genetic study status of PTSD and explore more reliable candidates, we obtained 105 PTSD related genetic studies by comprehensively literature searching and filtering 1762 studies. Detailed phenotype and sample information for each study and association results for each genetic marker were extracted. Based on the extracted data, we reviewed the PTSD genetic research status and further conducted bioinformatics analyses for the genetic data. Our analyses summarized the landscape of PTSD genetic studies, identified the genes with most genetic evidence, discovered the biological function of the candidate variants/genes and enlarged the overall candidates for future investigations. All the data were stored in the PTSDgene database (http://ptsdgene.psych.ac.cn). We hope PTSDgene could be a platform for the rapid growth of PTSD genetic data and provide new insights into the pathogenesis of PTSD.
创伤后应激障碍（PTSD）是一种具有复杂病因的致残性精神疾病。旨在探索 PTSD 的遗传易感性和环境诱因的研究一直在增加。然而，研究结果有限且高度异质。为了了解 PTSD 的遗传研究现状并探索更可靠的候选者，我们通过全面的文献搜索获得了 105 项与 PTSD 相关的遗传研究，并筛选了 1762 项研究。从每项研究中提取了详细的表型和样本信息以及每个遗传标记的关联结果。基于提取的数据，我们回顾了 PTSD 遗传研究的现状，并进一步对遗传数据进行了生物信息学分析。我们的分析总结了 PTSD 遗传研究的概况，确定了具有最多遗传证据的基因，发现了候选变异/基因的生物学功能，并扩大了未来研究的总体候选者。所有数据都存储在 PTSDgene 数据库（http://ptsdgene.psych.ac.cn）中。我们希望 PTSDgene 能够成为 PTSD 遗传数据快速增长的平台，并为 PTSD 的发病机制提供新的见解。
