Richardson A, Bayliss J, Scriven A J, Parameshwar J, Poole-Wilson P A, Sutton G C
Hillingdon Hospital, Uxbridge, Middlesex.
Lancet. 1987 Sep 26;2(8561):709-11. doi: 10.1016/s0140-6736(87)91074-9.
Captopril alone as therapy for mild heart failure was compared with a combination of frusemide and amiloride in a double-blind randomised crossover trial in 14 patients who had previously been treated with diuretics. Although 10 patients remained stable on captopril alone, 4 patients deteriorated, with the development of pulmonary oedema of breathlessness. All 4 patients had had pulmonary oedema previously, unlike the patients who remained stable. Angiotensin converting enzyme inhibition alone is not sufficient treatment for patients with mild heart failure and a history of overt pulmonary oedema.
