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How can we predict cellular mechanosensation?: Comment on "Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses" by Bo Cheng et al.

作者信息

Wu Jingwen, LeDuc Philip, Steward Robert

机构信息

Departments of Mechanical and Aerospace Engineering, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States.

Departments of Mechanical Engineering, Biomedical Engineering, Computational Biology, and Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States.

出版信息

Phys Life Rev. 2017 Dec;22-23:120-122. doi: 10.1016/j.plrev.2017.08.013. Epub 2017 Sep 1.

DOI:10.1016/j.plrev.2017.08.013
PMID:28890169
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5908231/
Abstract
摘要

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A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells.一种基于化学机械自由能的方法，用于模拟细胞的趋硬性以及细胞外刚度依赖性收缩和极化。
Interface Focus. 2016 Feb 6;6(1):20150067. doi: 10.1098/rsfs.2015.0067.
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Systems mechanobiology: tension-inhibited protein turnover is sufficient to physically control gene circuits.系统力学生物学：张力抑制的蛋白质周转足以从物理上控制基因回路。
Biophys J. 2014 Dec 2;107(11):2734-43. doi: 10.1016/j.bpj.2014.10.042.
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Dynamics of cell shape and forces on micropatterned substrates predicted by a cellular Potts model.基于细胞 Potts 模型预测微图案化基底上细胞形状和力的动力学。
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