Monteil M, Hobbs J, Citron K
Department of Chemical Immunology, Charing Cross and Westminster Medical School, London.
Lancet. 1987 Oct 17;2(8564):880-3. doi: 10.1016/s0140-6736(87)91372-9.
Eight patients with recurrent staphylococcal infections, necessitating up to 213 hospital admissions in one patient, gave normal results with the usual immunological investigations, including measurement of serum IgG and IgG2. In the staphylococcal inhibition test all showed persistently subnormal results, corrected by the addition of compatible normal plasma or normal IgG therapy for 6 months to 21 years, and one died from staphylococcal septicaemia 6 months after withdrawal of treatment. The impairment in anti-staphylococcal response, with failure to produce adequate antibodies, was probably acquired in utero in four patients and inherited in two. In these six patients symptoms started soon after 4 months. In the remaining two the syndrome was acquired later in life.
8例复发性葡萄球菌感染患者，其中1例患者住院多达213次，常规免疫检查（包括血清IgG和IgG2测定）结果均正常。在葡萄球菌抑制试验中，所有患者结果均持续低于正常水平，加入相容的正常血浆或进行6个月至21年的正常IgG治疗后结果得到纠正，1例患者在停止治疗6个月后死于葡萄球菌败血症。4例患者抗葡萄球菌反应受损、无法产生足够抗体的情况可能是在子宫内获得的，2例为遗传性。这6例患者在4个月后不久即出现症状。其余2例患者的综合征是在生命后期获得的。
