Grace James L, Alcaraz Nicolas, Truong Nghia P, Davis Thomas P, Boyd Ben J, Quinn John F, Whittaker Michael R
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Chem Commun (Camb). 2017 Sep 21;53(76):10552-10555. doi: 10.1039/c7cc05842j.
Lipidated polymers, like their protein counterparts, may be useful in fields as diverse as biochemistry and drug delivery. As such, strategies for preparing lipidated polymers with defined molecular architecture are clearly warranted. Herein, we describe a broadly-applicable methodology for synthesizing such lipidated materials, and demonstrate how they can be applied to the preparation of nanostructured drug delivery vehicles.
脂质化聚合物与其蛋白质类似物一样，在生物化学和药物递送等诸多领域可能都有用处。因此，明确需要制定策略来制备具有确定分子结构的脂质化聚合物。在此，我们描述了一种广泛适用的合成此类脂质化材料的方法，并展示了它们如何应用于制备纳米结构药物递送载体。
