INSERM U1053, University of Bordeaux, Bordeaux, France.
National Reference Center for Helicobacters, Bacteriology laboratory, CHU de Bordeaux, France.
Helicobacter. 2017 Sep;22 Suppl 1. doi: 10.1111/hel.12404.
Important progress is being made in endoscopic methods which allow clinicians to predict the presence of Helicobacter pylori based on characteristics of gastric mucosa and to obtain targeted biopsies. There are also important developments in molecular methods with various techniques derived from standard PCR, applied both on gastric biopsies and stool specimens. Progress is being made in microfluidic systems to get a reliable diagnosis in a very short time. The interest of the C urea breath test has been confirmed as well as stool antigen tests. Attempts are being made to find biological markers of premalignant conditions by serology, other than pepsinogens.
在内镜方法方面取得了重要进展，使临床医生能够根据胃黏膜的特征预测幽门螺杆菌的存在，并进行有针对性的活检。在分子方法方面也有重要进展，各种衍生自标准 PCR 的技术既应用于胃活检标本，也应用于粪便标本。在微流控系统方面也取得了进展，以便在极短的时间内获得可靠的诊断。C 尿素呼气试验和粪便抗原检测的应用也得到了证实。除了胃蛋白酶原之外，还在通过血清学寻找癌前状态的生物标志物方面进行了尝试。
