1 Monash Alfred Psychiatry Research Centre (MAPrc), Melbourne, VIC, Australia.
2 Monash University, Melbourne, VIC, Australia.
Aust N Z J Psychiatry. 2018 Feb;52(2):117-128. doi: 10.1177/0004867417730650. Epub 2017 Sep 9.
This review examines the existing evidence for the relationship between borderline personality disorder and polycystic ovary syndrome, and to identify commonalities in etiological mechanisms of borderline personality disorder and polycystic ovary syndrome that might explain the relationship between these seemingly disparate disorders.
A search of Medline, EMBASE and Cochrane Central was undertaken on 5 December 2016 to identify studies investigating women with borderline personality disorder and polycystic ovary syndrome (or symptoms and markers specific to polycystic ovary syndrome).
Nine studies were identified, including three cross-sectional studies investigating symptoms of polycystic ovary syndrome in women with borderline personality disorder, two cross-sectional and one cohort study examining the prevalence of psychiatric diagnoses in women with polycystic ovary syndrome and three case reports of comorbid borderline personality disorder and polycystic ovary syndrome.
Overall, the literature shows women with borderline personality disorder to have higher than expected serum androgen levels and incidence of polycystic ovaries, which can be key features of polycystic ovary syndrome. However, this research is still in its infancy, which limits our understanding of this potential comorbid phenomenon. Given the emerging anecdotal and empirical evidence to date, a theoretical discussion of the potential psychoneuroendocrinological mechanism underlying the borderline personality disorder and polycystic ovary syndrome comorbidity is provided. Further rigorous studies using standardized diagnostic criteria for polycystic ovary syndrome are warranted. Specifically, the use of prospective controlled cohort studies may be able to determine the causality and temporality of observed comorbid borderline personality disorder and polycystic ovary syndrome.
本综述考察了边缘型人格障碍与多囊卵巢综合征之间的现有证据，并确定边缘型人格障碍和多囊卵巢综合征的发病机制中的共性，这些共性可能解释了这两种看似不同的疾病之间的关系。
2016 年 12 月 5 日，我们对 Medline、EMBASE 和 Cochrane Central 进行了检索，以确定研究边缘型人格障碍和多囊卵巢综合征（或多囊卵巢综合征特定的症状和标志物）女性的研究。
共确定了 9 项研究，包括 3 项横断面研究，调查了边缘型人格障碍女性的多囊卵巢综合征症状，2 项横断面研究和 1 项队列研究，调查了多囊卵巢综合征女性的精神诊断患病率，以及 3 项关于合并边缘型人格障碍和多囊卵巢综合征的病例报告。
总体而言，文献表明边缘型人格障碍女性的血清雄激素水平和多囊卵巢发生率高于预期，这可能是多囊卵巢综合征的关键特征。然而，这项研究仍处于起步阶段，这限制了我们对这种潜在共病现象的理解。鉴于迄今为止出现的轶事和经验证据，我们提供了潜在的边缘型人格障碍和多囊卵巢综合征共病的心理神经内分泌机制的理论讨论。需要进一步使用多囊卵巢综合征的标准化诊断标准进行严格的研究。具体来说，前瞻性对照队列研究的使用可能能够确定观察到的共病边缘型人格障碍和多囊卵巢综合征的因果关系和时间性。
