一种新型载紫杉醇聚合物：聚乙二醇-聚己内酯修饰的磁性氧化铁纳米颗粒的增强肿瘤靶向作用
Enhanced tumor targeting effects of a novel paclitaxel-loaded polymer: PEG-PCCL-modified magnetic iron oxide nanoparticles.
作者信息
Li Xinyi, Yang Yuan, Jia Yiping, Pu Xuan, Yang Ting, Wang Yicheng, Ma Xuefei, Chen Qi, Sun Mengwen, Wei Dapeng, Kuang Yu, Li Yang, Liu Yu
机构信息
a Department of Microbiology, West China School of Basic Medical Sciences & Forensic Medicine , Sichuan University , Chengdu , China.
b State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics , West China Hospital of Stomatology, Sichuan University , Chengdu , China.
出版信息
Drug Deliv. 2017 Nov;24(1):1284-1294. doi: 10.1080/10717544.2017.1373167.
BACKGROUND
Multifunctional magnetic nanoparticles (MNP) have been newly developed for tumor-targeted drug carriers. To address challenges including biocompatibility, stability, nontoxicity, and targeting efficiency, here we report the novel drug deliverer poly(ethylene glycol) carboxyl-poly(ɛ-caprolactone) modified MNP (PEG-PCCL-MNP) suitable for magnetic targeting based on our previous studies.
METHODS
Their in vitro characterization and cytotoxicity assessments, in vivo cytotoxicity assessments, and antitumor efficacy study were elaborately investigated.
RESULTS
The size of PEG-PCCL-MNP was 79.6 ± 0.945 nm. PEG-PCCL-MNP showed little in vitro or in vivo cytotoxicity and good biocompatibility, as well as effective tumor-specific cell targeting for drug delivery with the presence of external magnetic field.
DISCUSSION
PEG-PCCL-MNP is a potential candidate of biocompatible and tumor-specific targeting drug vehicle for hydrophobic drugs.
背景
多功能磁性纳米颗粒（MNP）作为肿瘤靶向药物载体已被新开发出来。为应对包括生物相容性、稳定性、无毒性和靶向效率等挑战，基于我们之前的研究，在此我们报告一种适用于磁靶向的新型药物递送剂聚（乙二醇）羧基 - 聚（ε - 己内酯）修饰的MNP（PEG - PCCL - MNP）。
方法
对其进行了详细的体外表征、细胞毒性评估、体内细胞毒性评估和抗肿瘤疗效研究。
结果
PEG - PCCL - MNP的尺寸为79.6 ± 0.945纳米。PEG - PCCL - MNP在体外或体内均显示出低细胞毒性和良好的生物相容性，并且在存在外部磁场的情况下对药物递送具有有效的肿瘤特异性细胞靶向作用。
讨论
PEG - PCCL - MNP是一种用于疏水性药物的具有生物相容性和肿瘤特异性靶向性的药物载体的潜在候选物。
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