Imperial College London, London, SW7 2AZ, United Kingdom.
St Andrews Centre for Plastic Surgery and Burns, Broomfield Hospital, Court Road, Broomfield, Chelmsford, CM1 7ET, United Kingdom.
Curr Stem Cell Res Ther. 2018;13(4):316-323. doi: 10.2174/1574888X11666170907120030.
Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, spine fusion and disc degeneration were included in this systematic review. Published articles up to January 2016 from MEDLINE, PubMed and Ovid were used by searching for specific terms. Of the 2595 articles found, 53 met the selection criteria and were included for analysis (16 on spinal cord injury, 28 on intervertebral disc repair and 9 on spinal fusion). Numerous studies reported better results when the mesenchymal stem cells were used in co-culture with other cells or used in scaffolds. Mesenchymal stem cells were also found to have an immune-modulatory role, which can improve surgical outcome. This systematic review suggests that mesenchymal stem cells can be used safely and effectively for these spinal surgery treatments. Whilst, in certain studies, mesenchymal stem cells did not necessarily show improved results from existing treatments, they provide an alternative option. This can reduce morbidity that arises from current surgical treatment.
脊柱手术对神经外科和骨科都提出了挑战。由于间充质干细胞具有异质性的分化潜能，因此人们对其在脊柱手术中的治疗作用非常感兴趣。本系统评价纳入了聚焦于间充质干细胞在脊髓损伤、脊柱融合和椎间盘退变治疗中的功效的动物和人体试验。通过搜索特定术语，使用 MEDLINE、PubMed 和 Ovid 中的已发表文章，直至 2016 年 1 月。在 2595 篇文章中，有 53 篇符合选择标准并被纳入分析（16 篇关于脊髓损伤，28 篇关于椎间盘修复，9 篇关于脊柱融合）。许多研究报告称，当间充质干细胞与其他细胞共培养或用于支架时，效果更好。间充质干细胞还具有免疫调节作用，可以改善手术结果。本系统评价表明，间充质干细胞可安全有效地用于这些脊柱手术治疗。虽然在某些研究中，间充质干细胞不一定显示出比现有治疗方法更好的效果，但它们提供了一种替代选择。这可以减少现有手术治疗引起的发病率。
