Laboratory of Sustainable Polymers, Department of Analytical Chemistry and Organic Chemistry, University Rovira i Virgili , Tarragona, Spain.
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6323, United States.
Biomacromolecules. 2017 Oct 9;18(10):3447-3456. doi: 10.1021/acs.biomac.7b01130. Epub 2017 Sep 27.
Ethyl lactate (EtLa), a green and safe agrochemical solvent, is gifted with some properties that make it a good candidate for SET-LRP. It dissolves CuBr, mediates an efficient disproportionation of CuBr in the presence of tris(2-(dimethylamino)ethyl)amine (Me-TREN), and is capable to dissolve both aqueous (polar) and hydrocarbon (nonpolar) soluble monomers and polymers. Here, we report that EtLa is an excellent solvent for the Cu(0) wire-catalyzed SET-LRP to produce both hydrophilic and hydrophobic polyacrylates that exhibit precise chain end functionality. These results will expand the table of SET-LRP solvents with a new green member of biological origin that is also biodegradable and, therefore, are expected to contribute to continue expanding the use of SET-LRP in the field of biomacromolecules, bioconjugates, and other biology and medicine related disciplines.
乳酸乙酯（EtLa）是一种绿色、安全的农用化学品溶剂，具有一些特性，使其成为连续电子转移自由基聚合（SET-LRP）的良好候选溶剂。它可以溶解 CuBr，在三（2-（二甲氨基）乙基）胺（Me-TREN）存在下介导 CuBr 的有效歧化反应，并且能够溶解水相（极性）和烃相（非极性）可溶性单体和聚合物。在这里，我们报告说 EtLa 是一种极好的溶剂，用于 Cu(0) 线催化的 SET-LRP，可制备具有精确链端官能团的亲水性和疏水性聚丙烯酸酯。这些结果将扩展 SET-LRP 溶剂表，增加一种新的绿色成员，这种成员具有生物起源，也是可生物降解的，因此有望有助于继续扩大 SET-LRP 在生物大分子、生物缀合物和其他与生物学和医学相关的领域中的应用。
