Rajchakit Urawadee, Sarojini Vijayalekshmi
School of Chemical Sciences, The University of Auckland , Private Bag, 92019 Auckland, New Zealand.
Bioconjug Chem. 2017 Nov 15;28(11):2673-2686. doi: 10.1021/acs.bioconjchem.7b00368. Epub 2017 Sep 26.
The escalation of multidrug-resistant pathogens has created a dire need to develop novel ways of addressing this global therapeutic challenge. Because of their antimicrobial activities, the combination of antimicrobial peptides (AMPs) and nanoparticles is a promising tool with which to kill drug-resistant pathogens. In recent years, several studies using AMP-nanoparticle conjugates, especially metallic nanoparticles, as potential antimicrobial agents against drug-resistant pathogens have been published. Among these, antimicrobial-peptide-conjugated gold nanoparticles (AMP-AuNPs) are particularly attractive because of the nontoxic nature of gold and the possibility of fine-tuning the AMP-NP conjugation chemistry. The following review discusses recent developments in the synthesis and antimicrobial activity studies of AMP-AuNPs. The classification of AMPs, their mechanisms of action, methods used for functionalizing AuNPs with AMPs, and the antimicrobial activities of the conjugates are discussed.
多重耐药病原体的不断增加迫切需要开发新方法来应对这一全球治疗挑战。由于其抗菌活性，抗菌肽（AMPs）与纳米颗粒的组合是一种很有前景的工具，可用于杀死耐药病原体。近年来，已经发表了几项使用AMP-纳米颗粒缀合物，特别是金属纳米颗粒作为抗耐药病原体潜在抗菌剂的研究。其中，抗菌肽缀合的金纳米颗粒（AMP-AuNPs）特别具有吸引力，因为金具有无毒性质，并且可以微调AMP-NP缀合化学。以下综述讨论了AMP-AuNPs合成及抗菌活性研究的最新进展。文中讨论了AMPs的分类、其作用机制、用AMPs功能化AuNPs的方法以及缀合物的抗菌活性。
