伴有或不伴有关节炎的常见自身免疫性皮肤病中抗环瓜氨酸肽自身抗体和C反应蛋白的评估

Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibodies and C-Reactive Protein in Common Autoimmune Skin Diseases with and without Arthritis.

作者信息

Kumari Bandana, Kumar Pawan, Chaudhary Radha Krishna Prasad

机构信息

Assistant Professor, Department of Biochemistry, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India.

Ex-Resident, Department of Radiology, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India.

出版信息

J Clin Diagn Res. 2017 Jul;11(7):BC06-BC08. doi: 10.7860/JCDR/2017/27234.10176. Epub 2017 Jul 1.

DOI:10.7860/JCDR/2017/27234.10176

PMID:28892879

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5583789/

Abstract

INTRODUCTION

Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation.

AIM

This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder.

MATERIALS AND METHODS

Serum anti-CCP antibodies and CRP was measured in 50 patients of autoimmune skin disease of which 28 were of psoriasis, 12 of Systemic Lupus Erythematosus (SLE) and 10 of Pemphigus Vulgaris (PV). These patients were categorised in two groups, with associated arthritis and without arthritis. The serum level of anti-CCP and CRP was correlated with the presence or absence of arthritis in these patients. Control group consists of 20 healthy subjects in which these two parameters were measured.

RESULTS

Out of total of 50 patients, anti-CCP was raised in 36.37% of patients with associated arthritis and 12.82% of patients without arthritis whereas CRP was raised in 63.63% of patients with arthritis and 35.89% of patients without arthritis. Mean serum anti-CCP in patient with arthritis was 15.78±13.94 U/ml and without arthritis was 7.56±7.68 U/ml with p=0.01 which was statistically significant. Mean serum CRP in arthritis was 21.11±15.51 mg/l and CRP without arthritis was 13.14±12.27 mg/l with p=0.07 which was statistically not significant.

CONCLUSION

Although both anti-CCP and CRP are valuable markers for autoimmune skin disorder, anti-CCP seems to show significant association with arthritis.

摘要

引言

抗环瓜氨酸肽（CCP）是类风湿性关节炎一种广为人知的诊断和预后重要标志物。C反应蛋白（CRP）是一种急性期蛋白，其水平会随着炎症反应而升高。

目的

本研究旨在探讨这两种标志物（抗CCP和CRP）在自身免疫性皮肤病中的作用及其与这些疾病中相关关节炎的关联。

材料与方法

检测了50例自身免疫性皮肤病患者的血清抗CCP抗体和CRP，其中28例为银屑病患者，12例为系统性红斑狼疮（SLE）患者，10例为寻常型天疱疮（PV）患者。这些患者被分为两组，一组有关节炎，另一组无关节炎。抗CCP和CRP的血清水平与这些患者是否患有关节炎相关。对照组由20名健康受试者组成，检测了这两个参数。

结果

在总共50例患者中，36.37%有关节炎的患者抗CCP升高，12.82%无关节炎的患者抗CCP升高；而63.63%有关节炎的患者CRP升高，35.89%无关节炎的患者CRP升高。有关节炎患者的平均血清抗CCP为15.78±13.94 U/ml，无关节炎患者为7.56±7.68 U/ml，p = 0.01，具有统计学意义。有关节炎患者的平均血清CRP为21.11±15.51 mg/l，无关节炎患者的CRP为13.14±12.27 mg/l，p = 0.07，无统计学意义。