Naqvi Akbar, Gopalakrishnan D, Bhasin Meenu Taneja, Sharma Nilima, Haider Khushtar, Martande Santosh
Lecturer, Department of Dentistry, HIMSR and HAHC Hospital, Hamdard University, New Delhi, India.
Professor and Head, Department of Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
J Clin Diagn Res. 2017 Jul;11(7):ZC09-ZC13. doi: 10.7860/JCDR/2017/23831.10149. Epub 2017 Jul 1.
Platelet-Rich Fibrin (PRF) and bioactive glass putty have been shown to be effective in promoting reduction in probing depth, gain in clinical attachment, and defect fill in intrabony periodontal defects. The individual role played by bioactive glass putty in combination with PRF is yet to be elucidated.
To compare the clinical effectiveness of the combination of PRF and bioactive glass putty and bioactive glass putty alone as regenerative techniques for intrabony defects in humans.
Ten pairs of intrabony defects were surgically treated with PRF and bioactive glass putty (Test group) on one side or bioactive glass putty alone (Control group) on other side. The primary outcomes of the study included changes in probing depth; attachment level and bone fill of osseous defect. The clinical parameters were recorded at baseline, 3, 6, and 9 months. Radiographic assessment was done using standardized intraoral periapical radiographs. Differences between baseline and postoperative measurementsbetween the control and test groups were calculated using independent t-test. Comparisons were made within each group between baseline, 3 months, 6 months and 9 months using the ANOVA test followed by Bonferroni test.
The mean probing depth reduction was greater in the test group (bioactive glass putty and PRF) i.e., (3.2±2.3 mm) than in the control group (bioactive glass putty alone) i.e., (3.15±1.06 mm). The mean CAL gain was also greater in the test group (4.1±1.73 mm) as compared to the control group (3.15±1.06 mm), (p-value<0.95). Furthermore significantly greater mean bone fill was found in the test group (7.1±1.37 mm) as compared to the control group (5.7 ± 1.64 mm), (p-value<0.043).
The results of this study showed both the groups bioactive glass putty alone (Control Group) and the combination of PRF and bioactive glass putty (Test Group) are effective in the treatment of intrabony defects. The bioactive glass putty appears to be a suitable vehicle to administer biologic substances like PRF and growth factors to induce the new bone regeneration.
富血小板纤维蛋白（PRF）和生物活性玻璃糊剂已被证明在促进牙周袋探诊深度降低、临床附着增加以及骨内牙周缺损的缺损填充方面有效。生物活性玻璃糊剂与PRF联合使用所起的个体作用尚待阐明。
比较PRF与生物活性玻璃糊剂联合应用和单独使用生物活性玻璃糊剂作为人类骨内缺损再生技术的临床效果。
10对骨内缺损患者，一侧采用PRF与生物活性玻璃糊剂联合治疗（试验组），另一侧单独使用生物活性玻璃糊剂（对照组）。该研究的主要结局包括探诊深度的变化、附着水平以及骨缺损的骨填充情况。在基线、3个月、6个月和9个月时记录临床参数。使用标准化口内根尖片进行影像学评估。使用独立t检验计算对照组和试验组基线与术后测量值之间的差异。使用方差分析（ANOVA）检验，随后进行Bonferroni检验，对每组基线、3个月、6个月和9个月的数据进行比较。
试验组（生物活性玻璃糊剂和PRF）的平均探诊深度降低幅度（3.2±2.3毫米）大于对照组（单独使用生物活性玻璃糊剂），即（3.15±1.06毫米）。试验组的平均临床附着水平增加量（4.1±1.73毫米）也高于对照组（3.15±1.06毫米），（p值<0.95）。此外，试验组的平均骨填充量（7.1±1.37毫米）显著高于对照组（5.7 ± 1.64毫米），（p值<0.043）。
本研究结果表明，单独使用生物活性玻璃糊剂组（对照组）和PRF与生物活性玻璃糊剂联合应用组（试验组）在治疗骨内缺损方面均有效。生物活性玻璃糊剂似乎是一种合适的载体，可用于输送诸如PRF和生长因子等生物物质以诱导新骨再生。
