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实验室中的恐惧消除是否能预测暴露疗法的结果?一项治疗模拟研究。

Does fear extinction in the laboratory predict outcomes of exposure therapy? A treatment analog study.

机构信息

Department of Psychiatry and Forensic Medicine, School of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain; Mental Health Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.

Department of Psychiatry and Forensic Medicine, School of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain; Specialized Department in Mental Health and Intellectual Disability, Institut Assistència Sanitària (IAS), Parc Hospitalari Martí i Julià, Salt, Catalonia, Spain.

出版信息

Int J Psychophysiol. 2017 Nov;121:63-71. doi: 10.1016/j.ijpsycho.2017.09.001. Epub 2017 Sep 8.

Abstract

Fear extinction models have a key role in our understanding of anxiety disorders and their treatment with exposure therapy. Here, we tested whether individual differences in fear extinction learning and fear extinction recall in the laboratory were associated with the outcomes of an exposure therapy analog (ETA). Fifty adults with fear of spiders participated in a two-day fear-learning paradigm assessing fear extinction learning and fear extinction recall, and then underwent a brief ETA. Correlational analyses indicated that enhanced extinction learning was associated with better ETA outcome. Our results partially support the idea that individual differences in fear extinction learning may be associated with exposure therapy outcome, but suggest that further research in this area is needed.

摘要

恐惧消退模型在我们理解焦虑障碍及其暴露疗法治疗方面起着关键作用。在这里,我们测试了实验室中恐惧消退学习和恐惧消退回忆的个体差异是否与暴露治疗模拟 (ETA) 的结果相关。50 名害怕蜘蛛的成年人参加了为期两天的恐惧学习范式,评估了恐惧消退学习和恐惧消退回忆,然后进行了简短的 ETA。相关分析表明,增强的消退学习与更好的 ETA 结果相关。我们的结果部分支持这样一种观点,即恐惧消退学习的个体差异可能与暴露疗法的结果有关,但这表明需要在这一领域进行进一步的研究。

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