Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Virus Res. 2018 Aug 2;254:10-14. doi: 10.1016/j.virusres.2017.09.005. Epub 2017 Sep 8.
Zika virus (ZIKV) was first isolated in 1947 from a rhesus monkey in the Zika forest of Uganda. ZIKV has since been silently circulating in a number of equatorial countries for over 50 years. The largest outbreak in humans occurred in Brazil in 2015-2016. Unlike its flavivirus relatives, sexual and post-transfusion transmissions of ZIKV have been reported. In addition, fetal infection can result in microcephaly and congenital Zikv syndrome has been reported in neonates. Moreover, ZIKV RNA can persist for at least 6 months in semen and 11 weeks in vaginal secretions after the infection, suggesting potential tropism for the male and female genital tracts. Accordingly, it is important to determine whether genital ZIKV infection could have deleterious effects on the male and female reproductive systems.
寨卡病毒（ZIKV）于 1947 年首次从乌干达寨卡丛林中的一只恒河猴中分离出来。此后，该病毒在多个赤道国家中已默默传播了 50 多年。2015-2016 年，巴西发生了最大规模的人类疫情。与其他黄病毒属病毒不同，寨卡病毒已被报告存在性传播和输血传播。此外，胎儿感染可导致小头畸形，且新生儿中已报告寨卡病毒先天性综合征。此外，寨卡病毒 RNA 可在感染后至少在精液中持续存在 6 个月，在阴道分泌物中持续存在 11 周，提示其对男性和女性生殖道具有潜在的嗜性。因此，确定生殖器寨卡病毒感染是否会对男性和女性生殖系统造成有害影响非常重要。
