寨卡病毒经性传播导致小鼠胎儿生长受限
Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.
作者信息
Uraki Ryuta, Jurado Kellie Ann, Hwang Jesse, Szigeti-Buck Klara, Horvath Tamas L, Iwasaki Akiko, Fikrig Erol
机构信息
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine.
Department of Immunobiology.
出版信息
J Infect Dis. 2017 Jun 1;215(11):1720-1724. doi: 10.1093/infdis/jix204.
Abstract
Zika virus (ZIKV) can be transmitted by mosquito bite or sexual contact. Using mice that lack the type I interferon receptor, we examined sexual transmission of ZIKV. Electron microscopy analyses showed association of virions with developing sperm within testes as well as with mature sperm within epididymis. When ZIKV-infected male mice were mated with naive female mice, the weight of fetuses at embryonic day 18.5 was significantly reduced compared with the control group. Additionally, we found ocular deformities in a minority of the fetuses. These results suggest that ZIKV causes fetal abnormalities after female mating with an infected male.
摘要
寨卡病毒（ZIKV）可通过蚊虫叮咬或性接触传播。我们利用缺乏I型干扰素受体的小鼠，对ZIKV的性传播进行了研究。电子显微镜分析显示，病毒粒子与睾丸内发育中的精子以及附睾内的成熟精子有关联。当感染ZIKV的雄性小鼠与未感染的雌性小鼠交配时，与对照组相比，胚胎第18.5天的胎儿体重显著降低。此外，我们在少数胎儿中发现了眼部畸形。这些结果表明，雌性与受感染雄性交配后，ZIKV会导致胎儿异常。
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