Pour P, Althoff J, Salmasi S Z, Stepan K
J Natl Cancer Inst. 1979 Sep;63(3):797-811. doi: 10.1093/jnci/63.3.797.
Hamsters of three types designated as inbred cream (Epp/e/e), linebred white (EPP/cdcd/RB/A), and linebred albino (EPP/cdcde/e) were thoroughly examined histopathologically for spontaneous diseases. All hamsters were maintained simultaneously for life under identical standard laboratory conditions. Marked differences were found in longevity of the animals and in incidence, sites, patterns, and types of spontaneous diseases. In cream hamsters (CH), survival time was shorter than in white hamsters (WH) and albino hamsters (AH). More tumors and malignant lesions unrelated to survival were found in AH compared to CH and WH; also, the multiplicity of neoplasms were more pronounced in AH. The predominating tumor types differed in each line: Pancreatic islet cell neoplasms were most common in CH, adrenal gland tumors predominated in WH, and thyroid gland tumors in AH. Also, the relative incidence of spontaneous tumors varied among the lines. Some tumors seemed strain-specific and were not seen in other lines; malignant melanomas, for example, occurred only in CH and WH. Certain neoplasms, e.g., those of the thyroid and adrenal glands, were found more often in one sex than the other. The three hamster groups differed also in nonneoplastic diseases. Detailed histopathologic findings are presented and compared with data on the Syrian golden hamster, the ancestral line of these three groups.
对三种类型的仓鼠进行了组织病理学的全面检查，以确定其自发性疾病。这三种仓鼠分别是近交系奶油色仓鼠（Epp/e/e）、品系繁育白色仓鼠（EPP/cdcd/RB/A）和品系繁育白化仓鼠（EPP/cdcde/e）。所有仓鼠在相同的标准实验室条件下同时终生饲养。结果发现，这些动物在寿命以及自发性疾病的发病率、发病部位、发病模式和类型方面存在显著差异。与白色仓鼠（WH）和白化仓鼠（AH）相比，奶油色仓鼠（CH）的存活时间较短。与CH和WH相比，AH中发现了更多与存活无关的肿瘤和恶性病变；此外，AH中的肿瘤多发性更为明显。每个品系中占主导地位的肿瘤类型各不相同：胰岛细胞瘤在CH中最为常见，肾上腺肿瘤在WH中占主导，甲状腺肿瘤在AH中占主导。此外，自发性肿瘤的相对发病率在不同品系之间也有所不同。一些肿瘤似乎具有品系特异性，在其他品系中未观察到；例如，恶性黑色素瘤仅发生在CH和WH中。某些肿瘤，如甲状腺和肾上腺肿瘤，在一种性别中比在另一种性别中更常见。这三组仓鼠在非肿瘤性疾病方面也存在差异。本文展示了详细的组织病理学发现，并与这三组仓鼠的祖先叙利亚金黄仓鼠的数据进行了比较。
