• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

烧伤患者脓毒症的预测与管理:当前观点

Predicting and managing sepsis in burn patients: current perspectives.

作者信息

Nunez Lopez Omar, Cambiaso-Daniel Janos, Branski Ludwik K, Norbury William B, Herndon David N

机构信息

Department of Surgery, University of Texas Medical Branch.

Shriners Hospitals for Children, Galveston, TX, USA.

出版信息

Ther Clin Risk Manag. 2017 Aug 29;13:1107-1117. doi: 10.2147/TCRM.S119938. eCollection 2017.

DOI:10.2147/TCRM.S119938
PMID:28894374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5584891/
Abstract

Modern burn care has led to unprecedented survival rates in burn patients whose injuries were fatal a few decades ago. Along with improved survival, new challenges have emerged in the management of burn patients. Infections top the list of the most common complication after burns, and sepsis is the leading cause of death in both adult and pediatric burn patients. The diagnosis and management of sepsis in burns is complex as a tremendous hypermetabolic response secondary to burn injury can be superimposed on systemic infection, leading to organ dysfunction. The management of a septic burn patient represents a challenging scenario that is commonly encountered by providers caring for burn patients despite preventive efforts. Here, we discuss the current perspectives in the diagnosis and treatment of sepsis and septic shock in burn patients.

摘要

现代烧伤护理使烧伤患者的存活率达到了前所未有的水平,而在几十年前,这些患者的损伤往往是致命的。随着存活率的提高,烧伤患者的管理也出现了新的挑战。感染是烧伤后最常见的并发症,脓毒症是成人和儿童烧伤患者死亡的主要原因。烧伤后脓毒症的诊断和管理很复杂,因为烧伤引起的巨大高代谢反应可能叠加在全身感染上,导致器官功能障碍。尽管采取了预防措施,但脓毒症烧伤患者的管理仍是烧伤护理人员常遇到的具有挑战性的情况。在此,我们讨论烧伤患者脓毒症和脓毒性休克诊断与治疗的当前观点。

相似文献

1
Predicting and managing sepsis in burn patients: current perspectives.烧伤患者脓毒症的预测与管理:当前观点
Ther Clin Risk Manag. 2017 Aug 29;13:1107-1117. doi: 10.2147/TCRM.S119938. eCollection 2017.
2
Detection of Infection and Sepsis in Burns.烧伤感染和脓毒症的检测。
Surg Infect (Larchmt). 2021 Feb;22(1):20-27. doi: 10.1089/sur.2020.348. Epub 2020 Oct 6.
3
Sepsis Care Pathway 2019.2019年脓毒症护理路径
Qatar Med J. 2019 Nov 7;2019(2):4. doi: 10.5339/qmj.2019.qccc.4. eCollection 2019.
4
Status and Challenges of Predicting and Diagnosing Sepsis in Burn Patients.烧伤患者脓毒症预测与诊断的现状及挑战
Surg Infect (Larchmt). 2018 Feb/Mar;19(2):168-175. doi: 10.1089/sur.2017.288. Epub 2018 Jan 12.
5
Sepsis in the burn patient: a different problem than sepsis in the general population.烧伤患者的脓毒症:与普通人群的脓毒症是不同的问题。
Burns Trauma. 2017 Aug 8;5:23. doi: 10.1186/s41038-017-0089-5. eCollection 2017.
6
The pathogenesis and diagnosis of sepsis post burn injury.烧伤后脓毒症的发病机制与诊断
Burns Trauma. 2021 Feb 4;9:tkaa047. doi: 10.1093/burnst/tkaa047. eCollection 2021 Jan.
7
Procalcitonin as a diagnostic biomarker for septic shock and bloodstream infection in burn patients from the Formosa Fun Coast dust explosion.降钙素原作为福尔摩沙垦丁乐园粉尘爆炸烧伤患者感染性休克和血流感染的诊断生物标志物。
J Microbiol Immunol Infect. 2017 Dec;50(6):872-878. doi: 10.1016/j.jmii.2016.08.021. Epub 2017 Jun 22.
8
CNS-Spleen Axis - a Close Interplay in Mediating Inflammatory Responses in Burn Patients and a Key to Novel Burn Therapeutics.中枢神经系统-脾脏轴在介导烧伤患者炎症反应中的密切相互作用,以及为烧伤治疗提供新策略的关键。
Front Immunol. 2021 Sep 1;12:720221. doi: 10.3389/fimmu.2021.720221. eCollection 2021.
9
Early application of continuous high-volume haemofiltration can reduce sepsis and improve the prognosis of patients with severe burns.早期应用持续高容量血液滤过可降低脓毒症发生率,改善严重烧伤患者的预后。
Crit Care. 2018 Jul 6;22(1):173. doi: 10.1186/s13054-018-2095-9.
10
Current pharmacotherapy for the treatment of severe burns.目前用于治疗严重烧伤的药物疗法。
Expert Opin Pharmacother. 2003 Mar;4(3):369-84. doi: 10.1517/14656566.4.3.369.

引用本文的文献

1
Early appropriate therapy with polymyxin B reduces the mortality in burn sepsis caused by carbapenem-resistant gram-negative bacteria: a retrospective analysis.早期使用多粘菌素B进行适当治疗可降低耐碳青霉烯类革兰氏阴性菌引起的烧伤脓毒症的死亡率:一项回顾性分析。
Eur J Clin Microbiol Infect Dis. 2025 Jun;44(6):1433-1442. doi: 10.1007/s10096-025-05119-3. Epub 2025 Apr 3.
2
Insights into bloodstream infections in South African paediatric burn patients: implications for antimicrobial stewardship.南非儿科烧伤患者血流感染的洞察:对抗菌药物管理的启示
BMC Infect Dis. 2025 Mar 14;25(1):362. doi: 10.1186/s12879-025-10582-6.
3
Identification of DNA damage repair-related genes in sepsis using bioinformatics and machine learning: An observational study.利用生物信息学和机器学习鉴定脓毒症中与DNA损伤修复相关的基因:一项观察性研究
Medicine (Baltimore). 2025 Jan 31;104(5):e41354. doi: 10.1097/MD.0000000000041354.
4
Biomarkers of sepsis in burn injury: an update.烧伤后脓毒症的生物标志物:最新进展
Burns Trauma. 2025 Jan 16;13:tkae080. doi: 10.1093/burnst/tkae080. eCollection 2025.
5
Predictors of Sepsis and Sepsis-related Mortality in Critically Ill Burn Patients: A Single Tertiary Care Center Experience.重症烧伤患者脓毒症及脓毒症相关死亡率的预测因素:单中心三级医疗中心经验
Plast Reconstr Surg Glob Open. 2024 Sep 18;12(9):e6180. doi: 10.1097/GOX.0000000000006180. eCollection 2024 Sep.
6
Recent alcohol intake impacts microbiota in adult burn patients.近期饮酒会影响成年烧伤患者的肠道菌群。
Alcohol. 2024 Aug;118:25-35. doi: 10.1016/j.alcohol.2024.04.003. Epub 2024 Apr 10.
7
Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries.血小板减少症在严重烧伤中的诊断和预后价值
Diagnostics (Basel). 2024 Mar 9;14(6):582. doi: 10.3390/diagnostics14060582.
8
An Overview of Recent Developments in the Management of Burn Injuries.烧伤治疗近期进展概述。
Int J Mol Sci. 2023 Nov 15;24(22):16357. doi: 10.3390/ijms242216357.
9
Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis.通过 ceRNA 网络构建和整合生物信息学分析鉴定脓毒症相关的免疫 lncRNA。
BMC Genomics. 2023 Aug 24;24(1):484. doi: 10.1186/s12864-023-09535-7.
10
Amino acid solution mitigates hypothermia response and intestinal damage following exertional heat stroke in male mice.氨基酸溶液可减轻雄性小鼠运动性中暑后低体温反应和肠道损伤。
Physiol Rep. 2023 May;11(10):e15681. doi: 10.14814/phy2.15681.

本文引用的文献

1
Practice Patterns and Outcomes Associated With Procalcitonin Use in Critically Ill Patients With Sepsis.脓毒症重症患者降钙素原使用的实践模式及相关结果
Clin Infect Dis. 2017 Jun 1;64(11):1509-1515. doi: 10.1093/cid/cix179.
2
Interleukin-10: A Compelling Therapeutic Target in Patients With Irritable Bowel Syndrome.白细胞介素-10:肠易激综合征患者极具吸引力的治疗靶点。
Clin Ther. 2017 Mar;39(3):632-643. doi: 10.1016/j.clinthera.2017.01.030. Epub 2017 Feb 23.
3
MR-proADM: A New Biomarker for Early Diagnosis of Sepsis in Burned Patients.中段前心钠素前体:烧伤患者脓毒症早期诊断的一种新生物标志物。
J Burn Care Res. 2017 Sep/Oct;38(5):290-298. doi: 10.1097/BCR.0000000000000508.
4
Changing trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unit.烧伤病房细菌分离株抗菌药物敏感性模式的变化趋势
Burns. 2017 Aug;43(5):1083-1087. doi: 10.1016/j.burns.2017.01.016. Epub 2017 Jan 30.
5
Management of Sepsis and Septic Shock.脓毒症和脓毒性休克的管理
JAMA. 2017 Feb 28;317(8):847-848. doi: 10.1001/jama.2017.0131.
6
Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department.Sepsis-3 标准对急诊科疑似感染患者住院死亡率的预后准确性。
JAMA. 2017 Jan 17;317(3):301-308. doi: 10.1001/jama.2016.20329.
7
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.拯救脓毒症运动:脓毒症和脓毒性休克管理国际指南:2016 年版。
Intensive Care Med. 2017 Mar;43(3):304-377. doi: 10.1007/s00134-017-4683-6. Epub 2017 Jan 18.
8
Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock.降钙素原评估对降低脓毒症、严重脓毒症或脓毒性休克成年患者死亡率的有效性和安全性。
Cochrane Database Syst Rev. 2017 Jan 18;1(1):CD010959. doi: 10.1002/14651858.CD010959.pub2.
9
The Use of Procalcitonin (PCT) for Diagnosis of Sepsis in Burn Patients: A Meta-Analysis.降钙素原(PCT)在烧伤患者脓毒症诊断中的应用:一项Meta分析
PLoS One. 2016 Dec 22;11(12):e0168475. doi: 10.1371/journal.pone.0168475. eCollection 2016.
10
Colistin-resistant Enterobacteriaceae infections: clinical and molecular characterization and analysis of in vitro synergy.耐黏菌素肠杆菌科细菌感染:临床及分子特征与体外协同作用分析
Diagn Microbiol Infect Dis. 2017 Mar;87(3):253-257. doi: 10.1016/j.diagmicrobio.2016.11.007. Epub 2016 Nov 15.