Veterans Health Administration, Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC) for Veteran Suicide Prevention, Rocky Mountain Regional Veterans Affairs Medical Center (RMRVAMC), Aurora, CO, USA; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Military and Veteran Microbiome: Consortium for Research and Education (MVM-CoRE), Aurora, CO, USA; Department of Systems Engineering and Management, Air Force Institute of Technology, Wright-Patterson Air Force Base, OH, USA.
Department of Surgery, Division of GI, Trauma, and Endocrine Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Alcohol. 2024 Aug;118:25-35. doi: 10.1016/j.alcohol.2024.04.003. Epub 2024 Apr 10.
Alcohol use is associated with an increased incidence of negative health outcomes in burn patients due to biological mechanisms that include a dysregulated inflammatory response and increased intestinal permeability. This study used phosphatidylethanol (PEth) in blood, a direct biomarker of recent alcohol use, to investigate associations between a recent history of alcohol use and the fecal microbiota, short chain fatty acids, and inflammatory markers in the first week after a burn injury for nineteen participants. Burn patients were grouped according to PEth levels of low or high and differences in the overall fecal microbial community were observed between these cohorts. Two genera that contributed to the differences and had higher relative abundance in the low PEth burn patient group were Akkermansia, a mucin degrading bacteria that improves intestinal barrier function, and Bacteroides, a potentially anti-inflammatory bacteria. There was no statistically significant difference between levels of short chain fatty acids or intestinal permeability across the two groups. To our knowledge, this study represents the first report to evaluate the effects of burn injury and recent alcohol use on early post burn microbiota dysbiosis, inflammatory response, and levels of short chain fatty acids. Future studies in this field are warranted to better understand the factors associated with negative health outcomes and develop interventional trials.
酒精的摄入会通过生物机制导致烧伤患者负面健康结果的发生率增加，这些机制包括失调的炎症反应和增加的肠道通透性。本研究使用血液中的磷脂酰乙醇（PEth），一种近期酒精使用的直接生物标志物，来调查在烧伤后第一周内，近期酒精使用史与粪便微生物群、短链脂肪酸和炎症标志物之间的关联，共涉及 19 名参与者。根据 PEth 水平的高低，将烧伤患者分为低水平或高水平组，并观察到这些队列之间整体粪便微生物群落存在差异。有两个属的相对丰度在低水平 PEth 烧伤患者组中更高，对这些差异有贡献，它们是阿克曼氏菌，一种能改善肠道屏障功能的粘蛋白降解细菌，以及拟杆菌，一种具有潜在抗炎作用的细菌。两组间短链脂肪酸或肠道通透性水平没有统计学上的显著差异。据我们所知，本研究首次评估了烧伤损伤和近期酒精使用对烧伤后早期微生物失调、炎症反应和短链脂肪酸水平的影响。该领域的未来研究是有必要的，以更好地了解与负面健康结果相关的因素，并开展干预试验。
