Abdollahzadeh Iman, Schwarten Melanie, Gensch Thomas, Willbold Dieter, Weiergräber Oliver H
Institute of Complex Systems, Structural Biochemistry (ICS-6), Forschungszentrum JülichJülich, Germany.
Institute of Complex Systems, Cellular Biophysics (ICS-4), Forschungszentrum JülichJülich, Germany.
Front Genet. 2017 Aug 28;8:109. doi: 10.3389/fgene.2017.00109. eCollection 2017.
Aging is a multifactorial process involving an accumulation of alterations on various organizational levels, which finally compromises viability and limits the lifespan of organisms. It is now well-established that many aspects of aging can be positively affected by (macro)autophagy, a mechanism of self-digestion found in virtually all eukaryotic cells. A comprehensive understanding of autophagy is thus expected to not only deepen our insight into the mechanisms of aging but to also open up new avenues toward increasing the healthy lifespan in humans. In this review, we focus on the Atg8 family of ubiquitin-like proteins, which play a crucial role in the autophagy process by virtue of their unique mode of reversible membrane association.
衰老 是一个多因素过程，涉及各个组织层面变化的积累，最终损害生存能力并限制生物体的寿命。现在已经明确，衰老的许多方面都可以受到（巨）自噬的积极影响，自噬是一种几乎在所有真核细胞中都存在的自我消化机制。因此，全面了解自噬不仅有望加深我们对衰老机制的认识，还能为延长人类健康寿命开辟新途径。在这篇综述中，我们聚焦于泛素样蛋白Atg8家族，它们凭借独特的可逆膜结合模式在自噬过程中发挥关键作用。
