Denu Ryan A, Hampton John M, Currey Adam, Anderson Roger T, Cress Rosemary D, Fleming Steven T, Lipscomb Joseph, Wu Xiao-Cheng, Wilson J Frank, Trentham-Dietz Amy
Medical Scientist Training Program, University of Wisconsin, 6068 WIMR, 1111 Highland Avenue, Madison, WI 53705, USA.
University of Wisconsin Carbone Cancer Center, 610 Walnut Street, Room 307, WARF Building, Madison, WI 53726, USA.
J Cancer Epidemiol. 2017;2017:7574946. doi: 10.1155/2017/7574946. Epub 2017 Aug 15.
Inflammatory breast cancer (IBC) is a rare yet aggressive form of breast cancer. We examined differences in patient demographics and outcomes in IBC compared to locally advanced breast cancer (LABC) and all other breast cancer patients from the Breast and Prostate Cancer Data Quality and Patterns of Care Study (POC-BP), containing information from cancer registries in seven states. Out of 7,624 cases of invasive carcinoma, IBC and LABC accounted for 2.2% ( = 170) and 4.9% ( = 375), respectively. IBC patients were more likely to have a higher number ( = 0.03) and severity ( = 0.01) of comorbidities than other breast cancer patients. Among IBC patients, a higher percentage of patients with metastatic disease versus nonmetastatic disease were black, on Medicaid, and from areas of higher poverty and more urban areas. Black and Hispanic IBC patients had worse overall and breast cancer-specific survival than white patients; moreover, IBC patients with Medicaid, patients from urban areas, and patients from areas of higher poverty and lower education had worse outcomes. These data highlight the effects of disparities in race and socioeconomic status on the incidence of IBC as well as IBC outcomes. Further work is needed to reveal the causes behind these disparities and methods to improve IBC outcomes.
炎性乳腺癌（IBC）是一种罕见但侵袭性强的乳腺癌形式。我们比较了炎性乳腺癌（IBC）与局部晚期乳腺癌（LABC）以及来自乳腺癌和前列腺癌数据质量与护理模式研究（POC - BP）的所有其他乳腺癌患者在人口统计学和预后方面的差异，该研究包含七个州癌症登记处的信息。在7624例浸润性癌病例中，炎性乳腺癌（IBC）和局部晚期乳腺癌（LABC）分别占2.2%（n = 170）和4.9%（n = 375）。与其他乳腺癌患者相比，炎性乳腺癌（IBC）患者更有可能患有更多数量（p = 0.03）和更严重（p = 0.01）的合并症。在炎性乳腺癌（IBC）患者中，转移性疾病患者与非转移性疾病患者相比，黑人、参加医疗补助计划者以及来自贫困程度较高地区和城市地区的患者比例更高。黑人及西班牙裔炎性乳腺癌（IBC）患者的总生存率和乳腺癌特异性生存率均低于白人患者；此外，参加医疗补助计划的炎性乳腺癌（IBC）患者、来自城市地区的患者以及来自贫困程度较高且教育程度较低地区的患者预后较差。这些数据凸显了种族和社会经济地位差异对炎性乳腺癌（IBC）发病率以及炎性乳腺癌（IBC）预后的影响。需要进一步开展工作以揭示这些差异背后的原因以及改善炎性乳腺癌（IBC）预后的方法。
