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L. 叶提取物减轻阿霉素诱导的心脏应激。

L. leaf extract alleviates doxorubicin induced cardiac stress.

作者信息

Bhatt Laxit, Joshi Viraj

机构信息

Department of Pharmacology, Shree Devi College of Pharmacy, Mangalore, Karnataka, India.

Department of Pharmacology & Toxicology, Zydus Research Centre, Ahmedabad, Gujarat, India.

出版信息

J Intercult Ethnopharmacol. 2017 Jul 12;6(3):284-289. doi: 10.5455/jice.20170701075019. eCollection 2017 Jul-Sep.

DOI:10.5455/jice.20170701075019
PMID:28894627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5580954/
Abstract

AIM

The study was undertaken to evaluate the cardioprotective effect of the alcoholic leaf extract of L. against cardiac stress caused by doxorubicin (DOX).

MATERIALS AND METHODS

Rats were treated with 100 mg/kg of leaf extract (MILE) in alone and interactive groups for 21 days. Apart from the normal and MILE control groups, all the groups were subjected to DOX (15 mg/kg, i.p.) toxicity for 21 days and effects of different treatments were analyzed by changes in serum biomarkers, tissue antioxidant levels, electrocardiographic parameters, lipid profile, and histopathological evaluation.

RESULTS

The MILE treated group showed decrease in serum biomarker enzyme levels and increase in tissue antioxidants levels. Compared to DOX control group, MILE treated animals showed improvement in lipid profile, electrocardiographic parameters, histological score, and mortality.

CONCLUSION

These findings clearly suggest the protective role of alcoholic leaf extract of against oxidative stress induced by DOX.

摘要

目的

本研究旨在评估[植物名称]酒精叶提取物对阿霉素（DOX）引起的心脏应激的心脏保护作用。

材料与方法

大鼠单独及交互组用100mg/kg叶提取物（MILE）处理21天。除正常组和MILE对照组外，所有组均接受DOX（15mg/kg，腹腔注射）毒性处理21天，并通过血清生物标志物、组织抗氧化水平、心电图参数、血脂谱和组织病理学评估的变化分析不同处理的效果。

结果

MILE处理组血清生物标志物酶水平降低，组织抗氧化剂水平升高。与DOX对照组相比，MILE处理的动物在血脂谱、心电图参数、组织学评分和死亡率方面有所改善。

结论

这些发现清楚地表明[植物名称]酒精叶提取物对DOX诱导的氧化应激具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a43/5580954/ea280254364c/JIE-6-284-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a43/5580954/ee5497e1620a/JIE-6-284-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a43/5580954/ea280254364c/JIE-6-284-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a43/5580954/ee5497e1620a/JIE-6-284-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a43/5580954/ea280254364c/JIE-6-284-g007.jpg

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