Bhatt Laxit, Sebastian Binu, Joshi Viraj
Department of Pharmacology, Shree Devi College of Pharmacy, Airport Road, Kenjar Village, Malavoor Panchayat, Mangalore, 575412 Karnataka, India.
Department of Pharmacology, Shree Devi College of Pharmacy, Airport Road, Kenjar Village, Malavoor Panchayat, Mangalore, 575412 Karnataka, India.
J Ayurveda Integr Med. 2017 Apr-Jun;8(2):62-67. doi: 10.1016/j.jaim.2017.04.006. Epub 2017 Jun 10.
Mangiferin is a highly potent antioxidant present in mango leaves which is utilized for therapeutic purposes.
The present study was undertaken to evaluate the cardioprotective effect of mangiferin against cyclophosphamide induced cardiotoxicity.
Rats were treated with 100 mg/kg of mangiferin in alone and interactive groups for 10 days. Apart from normal and mangiferin control groups, all the groups were subjected to cyclophosphamide (200 mg/kg, i.p.) toxicity on Day 1 and effects of different treatments were analyzed by changes in serum biomarkers, tissue antioxidant levels, electrocardiographic parameters, lipid profile and histopathological evaluation.
Mangiferin treated group showed decrease in serum biomarker enzyme levels and increase in tissue antioxidant levels. Compared to cyclophosphamide control group, mangiferin treated animals showed improvement in lipid profile, electrocardiographic parameters, histological score and mortality.
The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.
芒果苷是一种存在于芒果叶中的高效抗氧化剂，可用于治疗目的。
本研究旨在评估芒果苷对环磷酰胺诱导的心脏毒性的心脏保护作用。
在单独给药组和交互给药组中，用100mg/kg的芒果苷对大鼠进行为期10天的治疗。除正常组和芒果苷对照组外，所有组在第1天接受环磷酰胺（200mg/kg，腹腔注射）毒性处理，并通过血清生物标志物、组织抗氧化水平、心电图参数、血脂谱和组织病理学评估的变化来分析不同处理的效果。
芒果苷治疗组血清生物标志物酶水平降低，组织抗氧化水平升高。与环磷酰胺对照组相比，芒果苷治疗的动物在血脂谱、心电图参数、组织学评分和死亡率方面有所改善。
目前的研究结果清楚地表明，芒果苷作为一种强大的抗氧化剂，对预防环磷酰胺引起的心脏毒性具有保护作用。
