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A novel classification system for perineural invasion in noncutaneous head and neck squamous cell carcinoma: histologic subcategories and patient outcomes.一种新型的非皮肤头颈部鳞状细胞癌神经周围侵犯分类系统：组织学亚类和患者预后。
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Perineural invasion in cancer: a review of the literature.癌症中的神经周围浸润：文献综述
Cancer. 2009 Aug 1;115(15):3379-91. doi: 10.1002/cncr.24396.
3
Patterns and incidence of neural invasion in patients with cancers of the paranasal sinuses.鼻窦癌患者神经侵犯的模式与发生率
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Perineural invasion: identification, significance, and a standardized definition.神经周围浸润：识别、意义及标准化定义
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Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial.选择性颈清扫术治疗早期舌癌N0颈部：需要进行一项随机对照试验。
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Survival following primary surgery for oral cancer.口腔癌初次手术后的生存情况。
Oral Oncol. 2009 Mar;45(3):201-11. doi: 10.1016/j.oraloncology.2008.05.008. Epub 2008 Jul 31.
8
Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival.口腔鳞状细胞癌：组织学风险评估而非切缘状态，是局部无病生存和总生存的强烈预测指标。
Am J Surg Pathol. 2005 Feb;29(2):167-78. doi: 10.1097/01.pas.0000149687.90710.21.
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Prognostic significance of perineural invasion in oral and oropharyngeal carcinoma.口腔及口咽癌中神经周围侵犯的预后意义
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Apr;97(4):423-31. doi: 10.1016/j.tripleo.2003.10.014.
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Adenoid cystic carcinoma of the head and neck--a 20 years experience.头颈部腺样囊性癌——20年经验总结
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口腔鳞状细胞癌中的神经周围浸润：组织学、肿瘤分期及预后

Perineural Invasion in Squamous Cell Carcinoma of the Oral Cavity: Histology, Tumor Stage, and Outcome.

作者信息

Laske Roman D, Scholz Irene, Ikenberg Kristian, Meerwein Christian, Vital Domenic G, Studer Gabriela, Rössle Matthias, Huber Gerhard F

机构信息

Department of Otorhinolaryngology Head and Neck Surgery.

Institute of Surgical Pathology.

出版信息

Laryngoscope Investig Otolaryngol. 2016 Jan 14;1(1):13-18. doi: 10.1002/lio2.4. eCollection 2016 Feb.

DOI:10.1002/lio2.4
PMID:28894798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5580858/
Abstract

OBJECTIVES/HYPOTHESIS: To analyze the impact of different types of perineural invasion (PNI) in squamous cell carcinoma (SCC) of the oral cavity on overall survival and recurrence rate, with a special focus on histologic subtypes and tumor stage.

STUDY DESIGN

Retrospective case-control study with clinicopathological analysis.

METHODS

Seventeen patients who received primary surgical treatment for SCC of the oral cavity with PNI were matched to a control group. In a histologic review, PNI was classified into subtypes according to an adapted Liebig classification. The term was used to describe tumor invasion into the nerve, whereas was used to describe circumferential growth around the nerve. Clinical charts were reviewed, and a Kaplan-Meier survival analysis was performed.

RESULTS

The recurrence-free survival rates were 47.1% versus 80.4% (PNI vs. matched control group,  < 0.05), 60.0% versus 94.1% (PNI in stage I and II disease vs. matched control group,  < 0.05) and 41.7% versus 73.5% (PNI in stage III and IV disease vs. matched control group,  < 0.05). In most cases (n = 9) of PNI, both histologic subtypes (type A and type B) were present. Five cases exclusively showed type A, and three cases exclusively showed type B.

CONCLUSIONS

Perineural invasion in early disease oral carcinoma has a particularly high impact on survival. Both histologic subtypes showed a significantly worse recurrence-free survival rate when compared to the control group.

LEVEL OF EVIDENCE

摘要

目的/假设：分析口腔鳞状细胞癌（SCC）中不同类型的神经周围浸润（PNI）对总生存率和复发率的影响，特别关注组织学亚型和肿瘤分期。

研究设计

采用回顾性病例对照研究并进行临床病理分析。

方法

将17例接受原发性手术治疗的伴有PNI的口腔SCC患者与一个对照组进行匹配。在组织学检查中，根据改良的利比希分类法将PNI分为不同亚型。术语“ ”用于描述肿瘤侵犯神经，而“ ”用于描述神经周围的环形生长。回顾临床病历，并进行Kaplan-Meier生存分析。

结果

无复发生存率分别为47.1%和80.4%（PNI组与匹配对照组相比， ＜0.05），60.0%和94.1%（I期和II期疾病中的PNI组与匹配对照组相比， ＜0.05），以及41.7%和73.5%（III期和IV期疾病中的PNI组与匹配对照组相比， ＜0.05）。在大多数PNI病例（n = 9）中，两种组织学亚型（A型和B型）均存在。5例仅表现为A型，3例仅表现为B型。

结论

早期口腔癌中的神经周围浸润对生存率有特别高的影响。与对照组相比，两种组织学亚型的无复发生存率均显著更差。

证据水平

3级。