Division of Neurology, Department of Medicine, Neuroscience and Mental Health Institute, University of Alberta, 7-132A Clinical Sciences Building, 11350-83 Ave, Edmonton, Alberta, T6G 2G3, Canada.
Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2G3, Canada.
J Neurovirol. 2017 Dec;23(6):919-921. doi: 10.1007/s13365-017-0576-2. Epub 2017 Sep 11.
Hantaviruses are a group of single-stranded RNA viruses of the Bunyaviridae family. "New World" hantaviruses cause hantavirus cardiopulmonary syndrome (HCPS) in North America. HCPS carries with it significant mortality and those patients who survive the disease are often left with substantial morbidity. Neurologic complications of hantavirus infections are rare, with only sparse cases of central nervous system involvement having been documented in the literature. To our knowledge, there are no reports of hantavirus infection contributing to peripheral nervous system dysfunction. Here we report a case of possible small fiber neuropathy associated with hantavirus infection, in a patient who survived HCPS. Persistent and treatment-resistant neuropathic pain may be a prominent feature in hantavirus-associated peripheral neuropathy.
汉坦病毒属于布尼亚病毒科的单链 RNA 病毒。“新世界”汉坦病毒会引起北美的汉坦病毒心肺综合征（HCPS）。HCPS 的死亡率很高，那些幸存下来的患者往往会留下严重的后遗症。汉坦病毒感染引起的神经系统并发症很少见，文献中只有少数中枢神经系统受累的病例被记录。据我们所知，尚无汉坦病毒感染导致周围神经系统功能障碍的报告。在这里，我们报告了一例可能与汉坦病毒感染相关的小纤维神经病的病例，该患者幸存于 HCPS。持续性和治疗抵抗性神经痛可能是汉坦病毒相关周围神经病变的一个突出特征。
