Guo Dianlin, Liu John, Gao Ran, Tari Samir, Islam Syed
a Employee of AbbVie Inc ., Chicago , Ilinois , USA.
b Former employee of AbbVie Inc ., Chicago , Ilinois , USA.
Ophthalmic Epidemiol. 2018 Feb;25(1):39-44. doi: 10.1080/09286586.2017.1339808. Epub 2017 Sep 12.
This database study aims to investigate the incidence and prevalence of optic neuritis (ON) among patients with different types of uveitis.
A retrospective analysis of the Truven Health MarketScan® database from 2000 to 2014 was conducted. Patients with uveitis were followed until diagnosis of ON or until they were censored. Diagnosis of uveitis and demyelinating diseases of the central nervous system (DD) including ON were based on ICD-9 codes. Patients with a diagnosis of DD at or before the index date of diagnosis of uveitis were excluded from incidence calculation. In the prevalence analysis, any diagnoses of DD during continuous enrollment were counted.
Among the 103,867 uveitis patients, 974 had ever been diagnosed with ON and 2121 with DD including ON during the continuous enrollment. Prevalence rates of ON in patients with intermediate, posterior and pan uveitis are approximately 2.0-2.5% while a lower prevalence (0.6%) of ON was observed in anterior uveitis. During a median follow-up period of 2.2 years, 463 new cases of ON were diagnosed. The incidence rates of ON per 100 person-years (95% CI) were 0.12 (0.11-0.13), 0.28 (0.18-0.41), 0.29 (0.23-0.35) and 0.38 (0.24-0.56), respectively, for anterior, intermediate, posterior and pan uveitis.
Incidence and prevalence of ON among patients with intermediate, posterior and pan uveitis were comparable and higher than the rates in patients with anterior uveitis.
本数据库研究旨在调查不同类型葡萄膜炎患者中视神经炎（ON）的发病率和患病率。
对2000年至2014年的Truven Health MarketScan®数据库进行回顾性分析。对葡萄膜炎患者进行随访，直至诊断出ON或进行截尾。葡萄膜炎和包括ON在内的中枢神经系统脱髓鞘疾病（DD）的诊断基于ICD - 9编码。在葡萄膜炎诊断索引日期或之前诊断为DD的患者被排除在发病率计算之外。在患病率分析中，计算连续入组期间DD的任何诊断情况。
在103,867例葡萄膜炎患者中，974例曾被诊断为ON，2121例在连续入组期间被诊断为包括ON在内的DD。中间、后部和全葡萄膜炎患者中ON的患病率约为2.0 - 2.5%，而前部葡萄膜炎患者中ON的患病率较低（0.6%）。在中位随访期2.2年期间，诊断出463例ON新病例。前部、中间、后部和全葡萄膜炎每100人年（95%CI）的ON发病率分别为0.12（0.11 - 0.13）、0.28（0.18 - 0.41）、0.29（0.23 - 0.35）和0.38（0.24 - 0.56）。
中间、后部和全葡萄膜炎患者中ON的发病率和患病率相当，且高于前部葡萄膜炎患者。
