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非酒精性脂肪性肝病:有何新发现?

NAFLD: Is There Anything New under the Sun?

机构信息

Division of Internal Medicine, Department of Biomedical, Metabolic and Neural Sciences, Azienda Ospedaliero-Universitaria, Ospedale Civile di Baggiovara, 41125 Modena, Italy.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy.

出版信息

Int J Mol Sci. 2017 Sep 12;18(9):1955. doi: 10.3390/ijms18091955.

DOI:10.3390/ijms18091955
PMID:28895919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5618604/
Abstract

Nonalcoholic fatty liver disease (NAFLD) is an "umbrella" definition that encompasses a spectrum of histological liver changes ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) with/without fibrosis, "cryptogenic" cirrhosis, and hepatocellular carcinoma (HCC), occurring in a dysmetabolic milieu, though in the absence of excessive alcohol consumption and other competing etiologies of chronic liver disease [1].[...].

摘要

非酒精性脂肪性肝病 (NAFLD) 是一个“伞状”定义,涵盖了一系列组织学肝脏变化,从单纯性脂肪变性到非酒精性脂肪性肝炎 (NASH) 伴/不伴纤维化、“隐源性”肝硬化和肝细胞癌 (HCC),发生在代谢异常的环境中,但不存在过量饮酒和其他慢性肝病的竞争病因 [1]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bea/5618604/953b5b62d3f9/ijms-18-01955-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bea/5618604/0425b49dcfc8/ijms-18-01955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bea/5618604/953b5b62d3f9/ijms-18-01955-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bea/5618604/0425b49dcfc8/ijms-18-01955-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bea/5618604/953b5b62d3f9/ijms-18-01955-g002.jpg

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本文引用的文献

1
The Telomeric Complex and Metabolic Disease.端粒复合体与代谢性疾病
Genes (Basel). 2017 Jul 7;8(7):176. doi: 10.3390/genes8070176.
2
Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases.非酒精性脂肪性肝病及其与心血管病和其他肝外疾病的关系。
Gut. 2017 Jun;66(6):1138-1153. doi: 10.1136/gutjnl-2017-313884. Epub 2017 Mar 17.
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Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis.与丙型肝炎病毒相关性肝硬化相比,隐源性肝硬化的临床特征及自然病史
Predicting Nonalcoholic Fatty Liver Disease through a Panel of Plasma Biomarkers and MicroRNAs in Female West Virginia Population.
通过西弗吉尼亚州女性群体血浆生物标志物和 microRNAs 预测非酒精性脂肪肝疾病。
Int J Mol Sci. 2020 Sep 13;21(18):6698. doi: 10.3390/ijms21186698.
4
Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD.非酒精性脂肪性肝病的发病机制、遗传、非侵入性临床、生化和评分方法概述。
Int J Environ Res Public Health. 2019 Sep 24;16(19):3570. doi: 10.3390/ijerph16193570.
5
Non-alcoholic fatty liver disease: a pandemic disease with multisystem burden.非酒精性脂肪性肝病:一种具有多系统负担的大流行性疾病。
Hepatobiliary Surg Nutr. 2018 Oct;7(5):389-391. doi: 10.21037/hbsn.2018.07.01.
6
Combined effects of synbiotic and sitagliptin versus sitagliptin alone in patients with nonalcoholic fatty liver disease.联合使用益生菌和西他列汀与单独使用西他列汀治疗非酒精性脂肪性肝病的效果比较。
Clin Mol Hepatol. 2018 Sep;24(3):331-338. doi: 10.3350/cmh.2018.0006. Epub 2018 Jun 12.
World J Gastroenterol. 2017 Feb 28;23(8):1458-1468. doi: 10.3748/wjg.v23.i8.1458.
4
Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease.非酒精性脂肪性肝病:慢性肾脏病的一个新的驱动因素。
Nat Rev Nephrol. 2017 May;13(5):297-310. doi: 10.1038/nrneph.2017.16. Epub 2017 Feb 20.
5
AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions.AISF关于非酒精性脂肪性肝病(NAFLD)的立场文件:更新与未来方向
Dig Liver Dis. 2017 May;49(5):471-483. doi: 10.1016/j.dld.2017.01.147. Epub 2017 Jan 23.
6
"Not all forms of NAFLD were created equal". Do metabolic syndrome-related NAFLD and PNPLA3-related NAFLD exert a variable impact on the risk of early carotid atherosclerosis?“并非所有形式的非酒精性脂肪性肝病都是一样的”。与代谢综合征相关的非酒精性脂肪性肝病和与PNPLA3相关的非酒精性脂肪性肝病对早期颈动脉粥样硬化风险的影响是否不同?
Atherosclerosis. 2017 Feb;257:253-255. doi: 10.1016/j.atherosclerosis.2017.01.008. Epub 2017 Jan 18.
7
Molecular Pathogenesis of NASH.非酒精性脂肪性肝炎的分子发病机制
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Int J Mol Sci. 2016 Sep 14;17(9):1545. doi: 10.3390/ijms17091545.
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The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe.美国和欧洲非酒精性脂肪性肝病的经济和临床负担。
Hepatology. 2016 Nov;64(5):1577-1586. doi: 10.1002/hep.28785. Epub 2016 Sep 26.
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Gene. 2016 Nov 15;593(1):162-166. doi: 10.1016/j.gene.2016.08.017. Epub 2016 Aug 9.