Guttman-Yassky Emma, Waldman Andrea, Ahluwalia Jusleen, Ong Peck Y, Eichenfield Lawrence F
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, New York, USA.
Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California, USA.
Semin Cutan Med Surg. 2017 Sep;36(3):100-103. doi: 10.12788/j.sder.2017.036.
Atopic Dermatitis (AD) is a complex inflammatory cutaneous disorder characterized by immune mediated inflammation and epidermal barrier dysfunction. Arising from a complex interplay between environmental and genetic factors, the definitive etiology of AD is perplexing and controversial. Advances in molecular medicine are radically transforming our understanding of AD pathogenesis. Increasing knowledge on the pathogenesis of AD results in novel therapeutic targets and pathways. This article details the pathogenesis section of the Curriculum United for Better Eczema Care (CUBE-C), facilitating primary care and sub-specialist education on the scientific advances driving recent AD therapeutic innovations.
特应性皮炎（AD）是一种复杂的炎症性皮肤病，其特征为免疫介导的炎症和表皮屏障功能障碍。AD由环境因素和遗传因素之间复杂的相互作用引起，其确切病因令人困惑且存在争议。分子医学的进展正在从根本上改变我们对AD发病机制的理解。对AD发病机制的了解不断增加，带来了新的治疗靶点和途径。本文详细介绍了改善湿疹护理联合课程（CUBE-C）的发病机制部分，促进初级保健和专科医生对推动近期AD治疗创新的科学进展的教育。
