Naz R K, Naylor P H, Goldstein A L
Department of Obstetrics and Gynecology, George Washington University Medical Center, Washington, D.C.
Int J Fertil. 1987 Sep-Oct;32(5):375-9.
High levels of thymosin alpha 1 (T alpha 1) were detected in human seminal plasma and follicular fluid. In the seminal plasma of 19 males studies, T alpha 1 levels varied from 614 to 2,604 pg/mL (mean +/- SD, 1,682.4 +/- 453.9 pg/mL). There was a correlation between the T alpha 1 levels and the total number of sperm in the ejaculate (r = .18) and seminal volume (r = .26). The infertile males, who had low levels of T alpha 1 also demonstrated fewer sperm, reduced motility, and lower semen volume. In follicular fluid collected from 24 follicles of 10 infertile females, T alpha 1 levels varied from 1,019 to 6,384 pg/mL (mean +/- SD, 3,572.8 +/- 1,599.7 pg/mL), which were higher when compared with the corresponding serum levels (mean +/- SD, 1,666.9 +/- 1,378.9 pg/mL). T alpha 1 levels present in follicular fluids which had "immature" oocytes were lower when compared with follicular fluids which had "intermediate" or "mature" oocytes. The immunoreactive T alpha 1 present in seminal plasma of males and in the follicular fluids of females may be involved in some aspect of germ cell maturation and function. The measurement of T alpha 1 levels may be useful in the diagnosis and treatment of male and female infertility, and also as a novel marker for the assessment of maturity of oocytes required for in vitro fertilization-embryo transfer.
在人类精液和卵泡液中检测到高水平的胸腺素α1（Tα1）。在对19名男性精液样本的研究中，Tα1水平在614至2604 pg/mL之间（平均值±标准差，1682.4±453.9 pg/mL）。Tα1水平与射精中精子总数（r = 0.18）和精液量（r = 0.26）之间存在相关性。Tα1水平较低的不育男性精子数量也较少，活力降低，精液量减少。在从10名不育女性的24个卵泡中收集的卵泡液中，Tα1水平在1019至6384 pg/mL之间（平均值±标准差，3572.8±1599.7 pg/mL），与相应的血清水平（平均值±标准差，1666.9±1378.9 pg/mL）相比更高。与含有“中等”或“成熟”卵母细胞的卵泡液相比，含有“未成熟”卵母细胞的卵泡液中Tα1水平较低。男性精液和女性卵泡液中存在的免疫反应性Tα1可能参与生殖细胞成熟和功能的某些方面。Tα1水平的测量可能有助于诊断和治疗男性和女性不育症，也可作为评估体外受精-胚胎移植所需卵母细胞成熟度的新型标志物。
