Isaacs D, Wilkinson A R, Moxon E R
Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford.
J Hosp Infect. 1987 Sep;10(2):114-9. doi: 10.1016/0195-6701(87)90136-8.
Twenty-seven newborns had an episode of late-onset sepsis (septicaemia or bacterial meningitis after 48 h of age) over an 18 month period. Preceding or simultaneous surface cultures were available from 26 babies. Colonization with the organism causing sepsis could only be documented in 10 cases. Colonization with aminoglycoside-resistant Gram negative organisms was common but there were only two cases of systemic sepsis with a resistant organism. Pseudomonas aeruginosa frequently colonized babies over the first 8 months of the survey, but subsequently virtually ceased to colonize babies, although it continued to be a common cause of late-onset sepsis. These findings do not support the utility of routine surveillance of organisms colonizing neonates in predicting bacteria causing late-onset sepsis. They also cast doubt on the value of eliminating colonizing organisms by expensive infection control measures.
在18个月的时间里，有27名新生儿发生了迟发性败血症（败血症或48小时龄后细菌性脑膜炎）。26名婴儿有先前或同时期的体表培养结果。仅在10例病例中记录到了导致败血症的病原体定植。氨基糖苷类耐药革兰阴性菌的定植很常见，但仅有2例系统性败血症是由耐药菌引起的。在调查的前8个月里，铜绿假单胞菌经常定植于婴儿，但随后几乎不再定植于婴儿，尽管它仍然是迟发性败血症的常见病因。这些发现不支持对定植于新生儿的病原体进行常规监测以预测导致迟发性败血症的细菌的实用性。它们也对通过昂贵的感染控制措施消除定植菌的价值提出了质疑。
