Ma Ling-Yan, Chen Xiao-Dan, He Yong, Ma Hui-Zi, Feng Tao
Eur Neurol. 2017;78(3-4):200-209. doi: 10.1159/000477902. Epub 2017 Aug 25.
BACKGROUND/AIMS: The topological organization of brain functional networks is impaired in Parkinson's disease (PD). However, the altered patterns of functional network hubs in different subtypes of PD are not completely understood.
3T resting-state functional MRI and voxel-based graph-theory analysis were employed to systematically investigate the intrinsic functional connectivity patterns of whole-brain networks. We enrolled 31 patients with PD (12 tremor dominant [TD] and 19 with postural instability/gait difficulty [PIGD]) and 22 matched healthy controls. Whole-brain voxel-wise functional networks were constructed by measuring the temporal correlations of each pair of brain voxels. Functional connectivity strength was calculated to explore the brain network hubs.
We found that both the TD and PIGD subtypes had comprehensive disrupted regions. These mainly involved the basal ganglia, cerebellum, superior temporal gyrus, pre- and postcentral gyri, inferior frontal gyrus, middle temporal gyrus, lingual gyrus, insula, and parahippocampal gyrus. Furthermore, the PIGD subgroup had more disrupted hubs in the cerebellum than the TD subgroup. These disruptions of hub connectivity were not correlated with the HY stage or disease duration.
Our results emphasize the subtype-specific PD-related degeneration of brain hubs, providing novel insights into the pathophysiological mechanisms of connectivity dysfunction in different PD subgroups.
背景/目的：帕金森病（PD）患者脑功能网络的拓扑组织受损。然而，不同亚型PD中功能网络枢纽的改变模式尚未完全明确。
采用3T静息态功能磁共振成像和基于体素的图论分析，系统研究全脑网络的内在功能连接模式。我们纳入了31例PD患者（12例震颤为主型[TD]和19例姿势不稳/步态障碍型[PIGD]）以及22名匹配的健康对照。通过测量每对脑体素的时间相关性构建全脑体素功能网络。计算功能连接强度以探索脑网络枢纽。
我们发现TD和PIGD亚型均有广泛的破坏区域。这些区域主要涉及基底神经节、小脑、颞上回、中央前回和中央后回、额下回、颞中回、舌回、岛叶和海马旁回。此外，PIGD亚组小脑的枢纽破坏比TD亚组更多。这些枢纽连接的破坏与Hoehn-Yahr（HY）分期或病程无关。
我们的结果强调了PD相关脑枢纽的亚型特异性退变，为不同PD亚组连接功能障碍的病理生理机制提供了新的见解。
